ArticlePloS one2018
RV adaptation to increased afterload in congenital heart disease and pulmonary hypertension.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.Journal of the Royal Society, Interface · 2026Article
- Hemodynamic and Thrombotic Vulnerability in Pulmonary Arterial Hypertension at High Altitude: Multivariable Predictors of Mortality.Medicina (Kaunas, Lithuania) · 2026Article
- Right and left heart morphology and function in dogs with compensated chronic right ventricular pressure overload secondary to pulmonic stenosis or precapillary pulmonary hypertension.The Canadian veterinary journal = La revue veterinaire canadienne · 2026Article
- Exercise Stress Echocardiography-Guided Balloon Pulmonary Valvuloplasty for Pulmonary Valve Stenosis With a Moderate Pressure Gradient and Exercise Intolerance: A Case Report.Case reports in cardiology · 2026Article
- Effect of a Systemic Right Ventricle With a Biventricular Circulation on Cardiorespiratory Fitness.CJC pediatric and congenital heart disease · 2025Article
- Increased Global Post-Systolic Contraction During 1st Interstage Predicts Medium-Term Death or Transplantation in Children With Hypoplastic Left Heart Syndrome.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume-loading.Physiological reports · 2025Article
- 3D regional evaluation of right ventricular myocardial work from cineCT.medRxiv : the preprint server for health sciences · 2024Article
- Right ventricular electromechanical dyssynchrony in adults with repaired Tetralogy of Fallot.Frontiers in pediatrics · 2023Article
- Echocardiographic Assessment of Right Ventricular Function in Paediatric Heart Disease: A Practical Clinical Approach.CJC pediatric and congenital heart disease · 2022Review
- A randomized controlled trial of enhancing hypoxia-mediated right cardiac mechanics and reducing afterload after high intensity interval training in sedentary men.Scientific reports · 2021Article
- Left Ventricle Phenotyping Utilizing Tissue Doppler Imaging in Premature Infants with Varying Severity of Bronchopulmonary Dysplasia.Journal of clinical medicine · 2021Article
- Echocardiographic assessment of the tricuspid and pulmonary valves: a practical guideline from the British Society of Echocardiography.Echo research and practice · 2020Article
- Patient-Specific Computational Analysis of Hemodynamics and Wall Mechanics and Their Interactions in Pulmonary Arterial Hypertension.Frontiers in bioengineering and biotechnology · 2020Article
- Evaluation of right ventricular diastolic function, systolic function, and circulating galectin-3 concentrations in dogs with pulmonary stenosis.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe various conditions causing a chronic increase of RV pressure greatly differ in the occurrence of RV failure, and in clinical outcome. To get a better understanding of the differences in outcome, RV remodeling, longitudinal function, and transverse function are compared between patients with pulmonary stenosis (PS), those with a systemic RV and those with pulmonary hypertension (PH). MATERIALS AND
methodsThis cross-sectional study prospectively enrolled subjects for cardiac magnetic resonance imaging (CMR), functional echocardiography and cardiopulmonary exercise testing. The study included: controls (n = 37), patients with PS (n = 15), systemic RV (n = 19) and PH (n = 20). Statistical analysis was performed using Analysis of Variance (ANOVA) with posthoc Bonferroni.
resultsPS patients had smaller RV volumes with higher RV ejection fraction (61.1±9.6%; p<0.05) compared to controls (53.8±4.8%). PH and systemic RV patients exhibited dilated RVs with lower RV ejection fraction (36.9±9.6% and 46.3±10.1%; p<0.01 versus controls). PH patients had lower RV stroke volume (p = 0.02), RV ejection fractions (p<0.01) and VO2 peak/kg% (p<0.001) compared to systemic RV patients. Mean apical transverse RV free wall motion was lower and RV free wall shortening (p<0.001) was prolonged in PH patients-resulting in post-systolic shortening and intra-ventricular dyssynchrony. Apical transverse shortening and global longitudinal RV deformation showed the best correlation to RV ejection fraction (respectively r = 0.853, p<0.001 and r = 0.812, p<0.001).
conclusionsRV remodeling and function differed depending on the etiology of RV pressure overload. In contrast to the RV of patients with PS or a systemic RV, in whom sufficient stroke volumes are maintained, the RV of patients with PH seems unable to compensate for its increase in afterload completely. Key mediators of RV dysfunction observed in PH patients, were: prolonged RV free wall shortening, resulting in post-systolic shortening and intra-ventricular dyssynchrony, and decreased transverse function.
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