Evidence map›Paper›PMID 30356123›Full record

ArticleNature communications2018

Efficient biosynthesis of heterodimeric C

Wenya Tian, Chenghai Sun, Mei Zheng, Jeffrey R Harmer, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Zixin Deng, Shi-Lu Chen and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Comparative Physiological and Metabolomic Responses ofAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. A nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C─C and C─N bonds.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Diversity-Oriented Catalytic Asymmetric Dearomatization of Indoles with o-Quinone Diimides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Total synthesis of complex 2,5-diketopiperazine alkaloids.The Alkaloids. Chemistry and biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenya TianKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Chenghai SunKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Mei ZhengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Jeffrey R HarmerCentre for Advanced Imaging, The University of Queensland, St. Lucia, QLD 4072, Australia.
Mingjia YuSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Yanan ZhangKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Haidong PengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Dongqing ZhuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Zixin DengKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.
Shi-Lu ChenSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, 100081, Beijing, China.
Mehdi MobliCentre for Advanced Imaging, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID http://orcid.org/0000-0003-2420-4262
Xinying JiaCentre for Advanced Imaging, The University of Queensland, St. Lucia, QLD 4072, Australia. x.jia1@uq.edu.au.ORCID http://orcid.org/0000-0003-0133-8321
Xudong QuKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China. quxd@whu.edu.cn.ORCID http://orcid.org/0000-0002-3301-8536

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31570057National Natural Science Foundation of China (National Science Foundation of China) 31770063
6 · The paper itself

Abstract

Many natural products contain the hexahydropyrrolo[2, 3-b]indole (HPI) framework. HPI containing chemicals exhibit various biological activities and distinguishable structural arrangement. This structural complexity renders chemical synthesis very challenging. Here, through investigating the biosynthesis of a naturally occurring C

Indexed as

AlkaloidsCytochrome P-450 Enzyme SystemDimerizationEscherichia coliMolecular StructureAlkaloidsCytochrome P-450 Enzyme System

Identifiers

PMID30356123
PMCPMC6200733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.