Evidence map›Paper›PMID 30356088›Full record

ArticleScientific reports2018

Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia.

Jitendra Kanaujiya, Edward Bastow, Raj Luxmi, Zhifang Hao, Dimitrios Zattas, Mark Hochstrasser, Ernst J Reichenberger, I-Ping Chen

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01630460 (Identification of Mutations That Lead to Craniometaphyseal Dysplasia in Families and Isolated Cases and Studies of Cellular and Molecular Mechanisms), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01630460 recruitingnot on this map

Identification of Mutations That Lead to Craniometaphyseal Dysplasia in Families and Isolated Cases and Studies of Cellular and Molecular Mechanisms

TypeobservationalSponsorUConn HealthRan2009 to 2030Enrolled600ConditionsCraniometaphyseal Dysplasia
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Restriction of Dietary Phosphate Ameliorates Skeletal Abnormalities in a Mouse Model for Craniometaphyseal Dysplasia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jitendra KanaujiyaDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030, United States.ORCID http://orcid.org/0000-0002-0701-2210
Edward BastowCenter for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health, Farmington, CT, 06030, United States.
Raj LuxmiDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030, United States.
Zhifang HaoDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030, United States.
Dimitrios ZattasProgram in Structural Biology, Sloan Kettering Institute, New York, NY, 10065, United States.
Mark HochstrasserDepartment of Molecular Biophysics and Biochemistry, Department of Molecular, Cellular and Development Biology, Yale University, New Haven, CT, 06520, United States.
Ernst J ReichenbergerCenter for Regenerative Medicine and Skeletal Development, Department of Reconstructive Sciences, University of Connecticut Health, Farmington, CT, 06030, United States.ORCID http://orcid.org/0000-0003-2229-2481
I-Ping ChenDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, 06030, United States. ipchen@uchc.edu.ORCID http://orcid.org/0000-0002-7349-3091
UConn Health · USKettering University · USYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Pathogenic Mechanisms of Craniometaphyseal DysplasiaR01DE025664 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI I-Ping Chen · 2016 to 2026
$4.5M
Degradation of Short Lived Regulatory Protein in YeastR37GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 2009 to 2018
$3.6M
DEGRADTION OF SHORT-LIVED REGULATORY PROTEINS IN YEASTR01GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 1992 to 2020
$3.6M
Control of Bone Formation in Craniometaphyseal DysplasiaR01DE019458 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI REICHENBERGER, ERNST J · 2011 to 2015
$1.8M
NCI NIH HHS P30 CA008748NIDCR NIH HHS R01 DE019458NIDCR NIH HHS R01 DE025664NIGMS NIH HHS R01 GM046904NIGMS NIH HHS R37 GM046904
6 · The paper itself

Abstract

Mutations in the progressive ankylosis protein (NP_473368, human ANKH) cause craniometaphyseal dysplasia (CMD), characterized by progressive thickening of craniofacial bones and widened metaphyses in long bones. The pathogenesis of CMD remains largely unknown, and treatment for CMD is limited to surgical intervention. We have reported that knock-in mice (Ank

Indexed as

AnimalsBone Diseases, DevelopmentalCells, CulturedCraniofacial AbnormalitiesHumansHyperostosisHypertelorismMiceMutationPhosphate Transport ProteinsProteasome Endopeptidase ComplexProtein StabilityRatsSaccharomyces cerevisiaeUbiquitinationANKH protein, humanPhosphate Transport ProteinsProteasome Endopeptidase Complex

Identifiers

PMID30356088
PMCPMC6200807
OpenAlexW2897653272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.