ArticleScientific reports2018
Imaging of Pseudomonas aeruginosa infection with Ga-68 labelled pyoverdine for positron emission tomography.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Selective PET imaging of bacterial infection using a glycosylatedNature biomedical engineering · 2026Article
- Identification of Siderophores With Unexpected Antibacterial Properties From Actinoplanes teichomyceticus.Chembiochem : a European journal of chemical biology · 2026Article
- A Siderophore-Antibiotic Heterodimer Imaging Agent EnablesJournal of medicinal chemistry · 2026Article
- Towards the Synthesis of Pyoverdines: Preparation and Reactivity of theMolecules (Basel, Switzerland) · 2026Article
- New insights into radiolabelled siderophores for molecular imaging of bacterial infections.Npj imaging · 2025Review
- Positron Emission Tomography Imaging ofACS infectious diseases · 2025Article
- The Role of Bacterial Siderophores in Infection Therapy: From Anti-Infective Mechanisms to Therapeutic Advances.International journal of nanomedicine · 2025Review
- Article
- Radiotracers for in situ infection imaging: Experimental considerations for in vitro microbial uptake of gallium-68-labeled siderophores.Diagnostic microbiology and infectious disease · 2024Article
- Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[ACS infectious diseases · 2024Article
- Automated Production of [Pharmaceutics · 2024Article
- [ACS infectious diseases · 2024Article
- Biosynthesis of a clickable pyoverdine via in vivo enzyme engineering of an adenylation domain.Microbial cell factories · 2024Article
- Peptidoglycan-Targeted [JACS Au · 2024Article
- Preclinical characterisation of gallium-68 labeled ferrichrome siderophore stereoisomers for PET imaging applications.EJNMMI radiopharmacy and chemistry · 2024Article
- Visualizing Bacterial Infections With Novel Targeted Molecular Imaging Approaches.The Journal of infectious diseases · 2023Article
- Imaging-Selected Host Responses in the Context of Infections.The Journal of infectious diseases · 2023Article
- Hydrocarbon degradation strategy and pyoverdine production using the salt tolerant Antarctic bacteriumRSC advances · 2023Article
- [Journal of medicinal chemistry · 2023Article
- Is Imaging Bacteria with PET a Realistic Option or an Illusion?Diagnostics (Basel, Switzerland) · 2023Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is an increasingly prevalent opportunistic pathogen that causes a variety of life-threatening nosocomial infections. Novel strategies for the development of new antibacterial treatments as well as diagnostic tools are needed. One of the novel diagnostic strategies for the detection of infection could be the utilization of siderophores. Siderophores are low-molecular-weight chelators produced by microbes to scavenge essential iron. Replacing iron in siderophores by suitable radiometals, such as Ga-68 for positron emission tomography (PET) imaging, opens approaches for targeted imaging of infection. Here we report on pyoverdine PAO1 (PVD-PAO1), a siderophore produced by P. aeruginosa, labelled with Ga-68 for specific imaging of Pseudomonas infections. PVD-PAO1 was labelled with Ga-68 with high radiochemical purity. The resulting complex showed hydrophilic properties, low protein binding and high stability in human serum. In vitro uptake of
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