Evidence map›Paper›PMID 30356017›Full record

ArticleMolecules (Basel, Switzerland)2018

HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis.

Seung Un Seo, Kyoung-Jin Min, Seon Min Woo, Ji Hae Seo, Taeg Kyu Kwon

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Seung Un SeoDepartment of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. ssu3885@gmail.com.
Kyoung-Jin MinDepartment of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. kyoungjin.min@gmail.com.
Seon Min WooDepartment of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. woosm724@gmail.com.
Ji Hae SeoDepartment of Biochemistry, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. seojihae7@gmail.com.
Taeg Kyu KwonDepartment of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, Korea. kwontk@dsmc.or.kr.ORCID 0000-0003-1204-2059
Keimyung University · KR

Funding

2018 Scholar Research Grant from Keimyung University .This work was supported by NRF grant funded by the Korea Government (MSIP) 2014R1A5A2010008, NRF-2016R1D1A1B03933568 and NRF-2016R1A2B2013393
6 · The paper itself

Abstract

We previously reported that PP242 (dual inhibitor of mTORC1/2) plus curcumin induced apoptotic cell death through lysosomal membrane permeabilization (LMP)-mediated autophagy. However, the relationship between ER stress and apoptotic cell death by combined PP242 and curcumin treatment remains unknown. In the present study, we found that combined PP242 and curcumin treatment induced cytosolic Ca

Indexed as

AcetylationApoptosisCalciumCell Line, TumorCell SurvivalCurcuminDrug SynergismEndoplasmic Reticulum StressHSP70 Heat-Shock ProteinsHumansMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Protein Kinase InhibitorsSignal TransductionCalciumCurcuminHSP70 Heat-Shock ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Protein Kinase InhibitorsacetylationcurcuminER stressHSP70mTORC1/2PP242

Identifiers

PMID30356017
PMCPMC6278488
OpenAlexW2898554163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.