Evidence map›Paper›PMID 30355984›Full record

ArticleInternational journal of molecular sciences2018

Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations.

Qinghua Wu, Wenda Wu, Tanos C C Franca, Vesna Jacevic, Xu Wang, Kamil Kuca

Open access · goldAbstract readEditorial
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. JNK Cascade-Induced Apoptosis-A Unique Role in GqPCR Signaling.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Killing Two Birds with One Stone: Mold-induced Pulmonary Immune Responses and Arterial Remodeling.American journal of respiratory cell and molecular biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Qinghua WuCollege of Life Science, Yangtze University, Jinzhou 434025, China. wqh212@hotmail.com.
Wenda WuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. wuwenda@njau.edu.cn.
Tanos C C FrancaLaboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Praça General Tiburcio 80, Rio de Janeiro 22290-270, RJ, Brazil. tanosfranca@gmail.com.ORCID 0000-0002-6048-8103
Vesna JacevicDepartment of Experimental Toxicology and Pharmacology, National Poison Control Center, Military Medical Academy, 11 Crnotravska St, 11 000 Belgrade, Republic of Serbia. v_jacevic@yahoo.com.ORCID 0000-0001-5137-2638
Xu WangNational Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China. wangxu@mail.hzau.edu.cn.
Kamil KucaDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03 Hradec Kralove, Czech Republic. kamil.kuca@uhk.cz.ORCID 0000-0001-9664-1109
Huazhong Agricultural University · CNMilitary Institute of Engineering · BRMilitary Medical Academy · RSNanjing Agricultural University · CNUniversity of Hradec Králové · CZYangtze University · CN

Funding

UHK Excellence Project
6 · The paper itself

Abstract

Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled "Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins" for the

Indexed as

Immune EvasionAnimalsHumansImmunosuppressive AgentsTrichothecenesImmunosuppressive AgentsTrichothecenesimmune evasionimmunotoxicitynegative immune regulationsT-2 toxintrichothecenes

Identifiers

PMID30355984
PMCPMC6275004
OpenAlexW2898607155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.