Evidence map›Paper›PMID 30355772›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Critical computational analysis illuminates the reductive-elimination mechanism that activates nitrogenase for N

Simone Raugei, Lance C Seefeldt, Brian M Hoffman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. A Proposed Complete-Cycle Mechanism for Conversion of NChembiochem : a European journal of chemical biology · 2026
    Article
  2. Article
  3. Article
  4. Oxidatively Induced Reductive NJournal of the American Chemical Society · 2025
    Article
  5. What Can be Learned From the Electrostatic Environments Within Nitrogenase Enzymes?Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  6. Synthetic models of the nitrogenase FeMo cofactor.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Terminal Hydride Complex of High-Spin Mn.Journal of the American Chemical Society · 2024
    Article
  13. Evaluating Diazene to NChemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simone RaugeiPhysical and Computational Sciences Directorate, Pacific Northwestern National Laboratory, Richland, WA 99352; simone.raugei@pnnl.gov lance.seefeldt@usu.edu bmh@northwestern.edu.
Lance C SeefeldtDepartment of Chemistry and Biochemistry, Utah State University, Logan, UT 84322; simone.raugei@pnnl.gov lance.seefeldt@usu.edu bmh@northwestern.edu.
Brian M HoffmanDepartment of Chemistry, Northwestern University, Evanston, IL 60208 simone.raugei@pnnl.gov lance.seefeldt@usu.edu bmh@northwestern.edu.ORCID 0000-0002-3100-0746

Funding

Coboglobins-Cobalt-Substituted Hemoglobins and MyoglobinR01GM111097 · NIGMS · NORTHWESTERN UNIVERSITY · PI HOFFMAN, BRIAN M · 2014 to 2025
$6.7M
NIGMS NIH HHS R01 GM111097
6 · The paper itself

Abstract

Recent spectroscopic, kinetic, photophysical, and thermodynamic measurements show activation of nitrogenase for N

Indexed as

CatalysisEnzyme ActivationHydrogenHydrogen BondingIron-Sulfur ProteinsMolecular Dynamics SimulationNitrogenNitrogenaseNitrogen FixationOxidation-ReductionProtonsStatic ElectricityThermodynamicsHydrogenIron-Sulfur ProteinsNitrogenNitrogenaseProtonscomputationDFTmechanismnitrogenase

Identifiers

PMID30355772
PMCPMC6233137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.