Evidence map›Paper›PMID 30355756›Full record

ArticleDisease models & mechanisms2018

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders.

Federico Tessadori, Helen I Roessler, Sanne M C Savelberg, Sonja Chocron, Sarah M Kamel, Karen J Duran, Mieke M van Haelst, Gijs van Haaften, Jeroen Bakkers

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 93 citations in OpenAlex.

  1. Treatment of overactive KScientific reports · 2025
    Trial
  2. Cantú Syndrome: A Poorly Understood Multi-Organ Disorder.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Advancing Knock-In Approaches for Robust Genome Editing in Zebrafish.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Engineering precision zebrafish alleles of human disease.bioRxiv : the preprint server for biology · 2025
    Article
  10. Broad Vitamin BInternational journal of molecular sciences · 2025
    Article
  11. Review
  12. Expanding the CRISPR/Cas toolkit: applications in proteomics and theranostics.Frontiers in bioengineering and biotechnology · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Federico TessadoriHubrecht Institute-KNAW and UMC Utrecht, 3584 CT Utrecht, the Netherlands.
Helen I RoesslerDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Sanne M C SavelbergDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Sonja ChocronHubrecht Institute-KNAW and UMC Utrecht, 3584 CT Utrecht, the Netherlands.
Sarah M KamelHubrecht Institute-KNAW and UMC Utrecht, 3584 CT Utrecht, the Netherlands.
Karen J DuranDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Mieke M van HaelstDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Gijs van HaaftenDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands G.vanHaaften@umcutrecht.nl j.bakkers@hubrecht.eu.ORCID 0000-0003-3033-0329
Jeroen BakkersHubrecht Institute-KNAW and UMC Utrecht, 3584 CT Utrecht, the Netherlands G.vanHaaften@umcutrecht.nl j.bakkers@hubrecht.eu.ORCID 0000-0002-9418-0422
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The zebrafish (

Indexed as

Gene EditingAnimalsBase SequenceCardiovascular DiseasesCRISPR-Associated Protein 9CRISPR-Cas SystemsDisease Models, AnimalGene Knock-In TechniquesGenetic TestingHeterozygoteHumansMutationNucleotidesZebrafishCRISPR-Associated Protein 9NucleotidesABCC9Cantú syndromeCRISPR/Cas9Genome editingKCNJ8Point mutationZebrafish

Identifiers

PMID30355756
PMCPMC6215435
OpenAlexW2897726150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.