Evidence map›Paper›PMID 30355731›Full record

ArticleThe Journal of biological chemistry2018

Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38.

Nicholas O Hudson, Frank G Whitby, Bethany A Buck-Koehntop

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Conformational dynamics in specialized CProtein science : a publication of the Protein Society · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. The remodeling of Z-DNA in the mammalian germ line.Biochemical Society transactions · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Proteins That Read DNA Methylation.Advances in experimental medicine and biology · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nicholas O HudsonFrom the Departments of Chemistry and.
Frank G WhitbyBiochemistry, University of Utah, Salt Lake City, Utah 84112.
Bethany A Buck-KoehntopFrom the Departments of Chemistry and koehntop@chem.utah.edu.ORCID 0000-0003-2421-7012
University of Montana · USUniversity of Utah · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

Methyl-CpG-binding proteins (MBPs) are selective readers of DNA methylation that play an essential role in mediating cellular transcription processes in both normal and diseased cells. This physiological function of MBPs has generated significant interest in understanding the mechanisms by which these proteins read and interpret DNA methylation signals. Zinc finger and BTB domain-containing 38 (ZBTB38) represents one member of the zinc finger (ZF) family of MBPs. We recently demonstrated that the C-terminal ZFs of ZBTB38 exhibit methyl-selective DNA binding within the ((A/G)TmCG(G/A)(mC/T)(G/A)) context both

Indexed as

DNA MethylationZinc FingersAmino Acid SequenceDNADNA ContaminationHumansModels, MolecularProtein BindingRepressor ProteinsDNARepressor ProteinsZBTB38 protein, humanDNA methylationDNA readerepigeneticsmethyl-CpG binding proteinprotein–DNA interactiontranscriptional regulationX-ray crystallographyzinc fingerzinc finger and BTB domain–containing protein

Identifiers

PMID30355731
PMCPMC6314133
OpenAlexW2898240191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.