Evidence map›Paper›PMID 30355694›Full record

ArticleJournal of virology2019

Human Norovirus Epitope D Plasticity Allows Escape from Antibody Immunity without Loss of Capacity for Binding Cellular Ligands.

Lisa C Lindesmith, Paul D Brewer-Jensen, Michael L Mallory, Boyd Yount, Matthew H Collins, Kari Debbink, Rachel L Graham, Ralph S Baric

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lisa C LindesmithDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Paul D Brewer-JensenDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Michael L MalloryDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Boyd YountDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Matthew H CollinsHope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, Georgia, USA.
Kari DebbinkDepartment of Natural Sciences, Bowie State University, Bowie, Maryland, USA.
Rachel L GrahamDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Ralph S BaricDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA rbaric@email.unc.edu.
University of North Carolina at Chapel Hill · USBowie State University · USEmory University · US

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
Mechanisms of Norovirus Protective ImmunityR56AI106006 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S · 2014 to 2014
$760k
NIAID NIH HHS R56 AI106006NIAID NIH HHS U19 AI109761Wellcome Trust 203268/Z/16/Z
6 · The paper itself

Abstract

Emergent strains of human norovirus seed pandemic waves of disease. These new strains have altered ligand binding and antigenicity characteristics. Study of viral variants isolated from immunosuppressed patients with long-term norovirus infection indicates that initial virus

Indexed as

INDEL MutationAntibodies, BlockingAntibodies, ViralCaliciviridae InfectionsCapsid ProteinsChildEpitopesFecesHumansImmunity, HerdLigandsNorovirusProtein BindingAntibodies, BlockingAntibodies, ViralCapsid ProteinsEpitopesLigandsantibody neutralizationantigenic driftblockade antibodyimmunocompromisednorovirusreceptor bindingviral evolution

Identifiers

PMID30355694
PMCPMC6321922
OpenAlexW2898162030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.