ArticleJournal of virology2019
BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation.
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Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses.Signal transduction and targeted therapy · 2025Article
- BCL6 inhibition: a promising approach to prevent germinal center-driven allo-immune responses.Frontiers in immunology · 2025Review
- Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen deficiency syndrome pattern.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.The Journal of clinical investigation · 2022Article
- Development of Droplet Digital PCR-Based Assays to Quantify HIV Proviral and Integrated DNA in Brain Tissues from Viremic Individuals with Encephalitis and Virally Suppressed Aviremic Individuals.Microbiology spectrum · 2022Article
- BCL6 BTB-specific inhibitor reversely represses T-cell activation, Tfh cells differentiation, and germinal center reaction in vivo.European journal of immunology · 2021Article
- Are HIV-1-Specific Antibody Levels Potentially Useful Laboratory Markers to Estimate HIV Reservoir Size? A Review.Frontiers in immunology · 2021Review
- Recommendations for measuring HIV reservoir size in cure-directed clinical trials.Nature medicine · 2020Review
- Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8Journal of virology · 2020Article
- BCL6 BTB-specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta).Journal of medical primatology · 2020Article
- Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6.Oncoimmunology · 2020Article
- Hepatitis B and HIV-1 2019 IAS Cure Forum: lessons and benefits from interdisciplinary research.Journal of virus eradication · 2019Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Yanhui CaiHIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Mohamed Abdel-MohsenHIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Costin TomescuHIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Fengtian XueDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Guoxin WuDepartment of Infectious Disease and Department of Biologics and Vaccine Formulations, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Bonnie J HowellDepartment of Infectious Disease and Department of Biologics and Vaccine Formulations, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Yong AiDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Jie SunDepartment of Immunology, Mayo Clinic School of Medicine, Rochester, Minnesota, USA.
Livio AzzoniHIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Carole Le CozDivision of Immunology and Allergy, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Neil RombergDivision of Immunology and Allergy, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Luis J MontanerHIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, Pennsylvania, USA montaner@wistar.org.
The Wistar Institute · USChildren's Hospital of Philadelphia · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Maryland, Baltimore · USMayo Clinic · US
Funding
UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3MVirus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MRole of Intestinal Barrier Integrity in Modulating the Host Glycome During COVID-19R01DK123733 · NIDDK · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, KESHAVARZIAN, ALI · 2020 to 2024
$4.5MMolecular regulation of protective CD8 immunity against influenza infectionR01AI112844 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2015 to 2024
$4.5MSialic Acid Modulation of HIV-associated Chronic InflammagingR01AG062383 · NIA · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2019 to 2023
$3.0MRegulation of pulmonary anti-viral immunity in normal and obese hostsR01HL126647 · NHLBI · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.9MSimultaneously boosting both humoral and cellular immunity following vaccinationR01AG047156 · NIA · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.6MBLOCKING AUTOANTIBODY SECRETION IN CVID PATIENTS WITH ITP BY IL-2 RESTORED TREGSK23AI115001 · NIAID · YALE UNIVERSITY · PI ROMBERG, NEIL DAVID · 2015 to 2019
$909kExploring Cell-free Glycomic Interactions in HIV-associated Neurological DisordersR21NS106970 · NINDS · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, NDHLOVU, LISHOMWA C · 2017 to 2018
$507kRole of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV LatencyR21AI129636 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2017 to 2018
$496kNCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016520NHLBI NIH HHS R01 HL126647NIAID NIH HHS K23 AI115001NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI112844NIAID NIH HHS R21 AI129636NIAID NIH HHS R21 AI143385NIAID NIH HHS UM1 AI126620NIA NIH HHS R01 AG047156
Abstract
Clearance of HIV-infected germinal center (GC) CD4
Indexed as
AdultCD4-Positive T-LymphocytesDown-RegulationHIV-1HIV-2HIV InfectionsHumansIndolesLymphocyte ActivationMiddle AgedPhosphorylationProto-Oncogene Proteins c-bcl-6SAM Domain and HD Domain-Containing Protein 1ThiazolidinedionesVirus ReplicationYoung AdultBCL6 protein, humanFX1 thiazolidinedione compoundIndolesProto-Oncogene Proteins c-bcl-6SAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanThiazolidinedionesBCL6HIV infectionSAMHD1T cell activationTfh
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.