Evidence map›Paper›PMID 30355665›Full record

ArticlemSphere2018

Cyclic Diguanylate Regulates Virulence Factor Genes via Multiple Riboswitches in

Robert W McKee, Carissa K Harvest, Rita Tamayo

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 60 citations in OpenAlex.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
  2. Journal of bacteriology · 2026
    Article
  3. Phase variable colony morphotypes ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. bioRxiv : the preprint server for biology · 2025
    Article
  7. Biofilm Dispersal inMicroorganisms · 2025
    Article
  8. Review
  9. Article
  10. The current riboswitch landscape inMicrobiology (Reading, England) · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. pGpG-signaling regulates virulence and global transcriptomic targets inbioRxiv : the preprint server for biology · 2024
    Article
  15. Biofilm Formation ofMicroorganisms · 2023
    Review
  16. Regulatory transcription factors ofCritical reviews in microbiology · 2023
    Review
  17. Microbiology (Reading, England) · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Robert W McKeeDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Carissa K HarvestDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Rita TamayoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA Rita_tamayo@med.unc.edu.ORCID 0000-0002-3745-3316
University of North Carolina at Chapel Hill · US

Funding

Regulation of Clostridium difficile Colonization FactorsR01AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2013 to 2022
$3.9M
Phase variation of virulence factors in Clostridioides difficileR37AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITA TAMAYO · 2025 to 2026
$1.0M
NIAID NIH HHS R01 AI107029NIAID NIH HHS R37 AI107029
6 · The paper itself

Abstract

The intracellular signaling molecule cyclic diguanylate (c-di-GMP) regulates many processes in bacteria, with a central role in controlling the switch between motile and nonmotile lifestyles. Recent work has shown that in

Indexed as

Bacterial ProteinsClostridioides difficileCyclic GMPGene Expression Regulation, BacterialRiboswitchVirulenceVirulence FactorsBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPRiboswitchVirulence Factorsbiofilmsc-di-GMPClostridium difficilecyclic diguanylateflagellar motilityriboswitch

Identifiers

PMID30355665
PMCPMC6200980
OpenAlexW2896593226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.