Evidence map›Paper›PMID 30355654›Full record

ArticleBioscience reports2018

Renal miR-148b is associated with megalin down-regulation in IgA nephropathy.

Lu Wen, Zhanzheng Zhao, Jing Xiao, Zheng Wang, Xiangfei He, Henrik Birn

Open access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Megalin: A Sidekick or Nemesis of the Kidney?Journal of the American Society of Nephrology : JASN · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. MicroRNAs in IgA nephropathy.Renal failure · 2021
    Review
  9. Review
  10. The effect of aryl hydrocarbon receptor ligands on gentamicin-induced nephrotoxicity in rats.Environmental science and pollution research international · 2020
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lu WenDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhanzheng ZhaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jing XiaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zheng WangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiangfei HeDepartment of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henrik BirnDepartment of Biomedicine, Aarhus University, Aarhus, Denmark hb@biomed.au.dk.ORCID 0000-0003-3715-7266
First Affiliated Hospital of Zhengzhou University · CNAarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Megalin is essential for proximal tubule reabsorption of filtered proteins, hormones, and vitamins, and its dysfunction has been reported in IgA nephropathy (IgAN). miR-148b has been shown to regulate renal megalin expression

Indexed as

AdultAnimalsAquaporin 1Cell LineFemaleGene Expression RegulationGlomerulonephritis, IGAHumansKidneyKidney Tubules, ProximalLow Density Lipoprotein Receptor-Related Protein-2MaleMicroRNAsMiddle AgedReceptors, Cell SurfaceRNA, MessengerAquaporin 1intrinsic factor-cobalamin receptorLow Density Lipoprotein Receptor-Related Protein-2MicroRNAsMIRN148 microRNA, humanReceptors, Cell SurfaceRNA, Messengercell transfectionIgA nephropathymegalinmicroRNArenal proximal tubule

Identifiers

PMID30355654
PMCPMC6239259
OpenAlexW2898220462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.