Evidence map›Paper›PMID 30355649›Full record

ArticleBioscience reports2018

Integrative genomic analysis for the functional roles of

Hsing-Fang Lu, Henry Sung-Ching Wong, Ben-Kuen Chen, Hsien-Tzung Liao, Yu-Wen Hsu, Shiro Ikegawa, Er-Chieh Cho, Kuo-Sheng Hung, Wei-Chiao Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hsing-Fang LuSchool of Pharmacy, Taipei Medical University, Taipei 11042, Taiwan.
Henry Sung-Ching WongSchool of Pharmacy, Taipei Medical University, Taipei 11042, Taiwan.
Ben-Kuen ChenDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Hsien-Tzung LiaoDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan.
Yu-Wen HsuThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11042, Taiwan.
Shiro IkegawaLaboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo 108-8639, Japan.
Er-Chieh ChoSchool of Pharmacy, Taipei Medical University, Taipei 11042, Taiwan.
Kuo-Sheng HungMaster Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11042, Taiwan kshung25@gmail.com wcc@tmu.edu.tw.
Wei-Chiao ChangSchool of Pharmacy, Taipei Medical University, Taipei 11042, Taiwan kshung25@gmail.com wcc@tmu.edu.tw.
Taipei Medical University · TWAcademia Sinica · TWNational Cheng Kung University · TWRIKEN Center for Integrative Medical Sciences · JPWan Fang Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis is defined by low bone mineral density (BMD), which is mainly due to the imbalances in osteoclast and osteoblast activity. Previous studies indicated that early activation of osteoclasts relies on calcium entry through store-operated calcium (SOC) entry, and several genes, including STIM1, ORAI1, and ITPKC, are known as key regulators of SOC entry. However, the relationships between

Indexed as

Genetic Association StudiesAgedBone DensityCalciumCalcium SignalingFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenomicsGenotypeHumansLumbar VertebraeMaleMiddle AgedNeoplasm ProteinsORAI1 ProteinCalciumInositol 1,4,5-trisphosphate 3-kinaseNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanPhosphotransferases (Alcohol Group Acceptor)STIM1 protein, humanStromal Interaction Molecule 1ITPKCosteoporosissingle nucleotide polymorphism

Identifiers

PMID30355649
PMCPMC6265621
OpenAlexW2898435810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.