ArticleBioscience reports2018
Antioxidative and antiphotoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 37 citations in OpenAlex.
- Inflammatory involvement into phototoxic reaction in erythropoietic protoporphyria (EPP) patients.Immunologic research · 2019Trial
- Action and mechanisms of neferine in inflammatory diseases (Review).Molecular medicine reports · 2025Review
- Biological and Therapeutic Responses of Human Skin to Different Wavelengths of Light: A Comprehensive Review.Journal of lasers in medical sciences · 2025Review
- Ergothioneine Protects Against UV-Induced Oxidative Stress Through the PI3K/AKT/Nrf2 Signaling Pathway.Clinical, cosmetic and investigational dermatology · 2024Article
- Human Serum Albumin/Selenium Complex Nanoparticles Protect the Skin from Photoaging Injury.International journal of nanomedicine · 2024Article
- Hulless barley polyphenol extract inhibits adipogenesis in 3T3-L1 cells and obesity related-enzymes.Frontiers in nutrition · 2022Article
- Anti-Allergic and Anti-Inflammatory Effects of Neferine on RBL-2H3 Cells.International journal of molecular sciences · 2021Article
- Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.International journal of molecular sciences · 2021Article
- Neferine prevents ultraviolet radiation-induced skin photoaging.Experimental and therapeutic medicine · 2020Article
Corrections and comments
- Erratum issued
- Expression of concern
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our daily exposure to ultraviolet radiation (UVR) results in the production of reactive oxygen species (ROS), lipids, proteins and DNA damage and alteration in fibroblast structure, thus contributing to skin photoaging. For this reason, the use of natural bioactive compounds with antioxidant activity could be a strategic tool to overcome ultraviolet A (UV-A) induced deleterious effect. Neferine is an alkaloid extract from the seed embryos of lotus (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.