Evidence map›Paper›PMID 30355617›Full record

ArticleThe Journal of experimental medicine2018

CD49b defines functionally mature Treg cells that survey skin and vascular tissues.

Xiying Fan, Bruno Moltedo, Alejandra Mendoza, Alexey N Davydov, Mehlika B Faire, Linas Mazutis, Roshan Sharma, Dana Pe'er, Dmitriy M Chudakov, Alexander Y Rudensky

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. CD38 endows local antigen-specific TNature immunology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Phenotypic and Functional Studies of Human Treg Cell Subpopulations.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiying FanHoward Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-3090-381X
Bruno MoltedoHoward Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9150-863X
Alejandra MendozaHoward Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY.
Alexey N DavydovCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Mehlika B FaireHoward Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY.
Linas MazutisSingle Cell Research Initiative, Memorial Sloan Kettering Cancer Center, New York, NY.
Roshan SharmaProgram for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY.
Dana Pe'erSingle Cell Research Initiative, Memorial Sloan Kettering Cancer Center, New York, NY.
Dmitriy M ChudakovCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Alexander Y RudenskyHoward Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY rudenska@mskcc.org.ORCID 0000-0003-1280-2898

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Self Peptides Bound to MHC Class II In T Cell SelectionR37AI034206 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI RUDENSKY, ALEXANDER Y · 2009 to 2018
$4.8M
Function of Regulatory T Cells in Tissue RepairF30AI122721 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FAN, XIYING · 2016 to 2019
$172k
Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748NIAID NIH HHS F30 AI122721NIAID NIH HHS R37 AI034206NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α

Indexed as

Immunologic SurveillanceAnimalsBlood VesselsIntegrin alpha2Lymph NodesMiceMice, TransgenicSkinT-Lymphocytes, RegulatoryIntegrin alpha2

Identifiers

PMID30355617
PMCPMC6219731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.