ArticleBMJ (Clinical research ed.)2018
Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 1 of them a synthesis that pooled it.
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Who cites it
167 citing papers in PubMed, 1 synthesis or guideline pooled it.
- European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.European stroke journal · 2024Guideline
- Late-Life Vascular Risk Score in Association With Postmortem Cerebrovascular Disease Brain Pathologies.Stroke · 2021Trial
- Combining Clinical and Polygenic Risk Improves Stroke Prediction Among Individuals With Atrial Fibrillation.Circulation. Genomic and precision medicine · 2021Trial
- Cognitive Impairment and Long-Term Cognitive Trajectories in Relation to Incident Sarcopenia.Annals of geriatric medicine and research · 2026Article
- Multimodal deep learning enhances genomic risk prediction for cardiometabolic diseases.Briefings in bioinformatics · 2026Article
- Associations between lifestyle, genetic liability for severe mental illness and risk of incident somatic illnesses.Translational psychiatry · 2026Article
- Where is the lifestyle medicine in the Canadian undergraduate medical education curricula? A content analysis.Canadian medical education journal · 2026Article
- Life's essential 8 factors and their impact on the risk of stroke and dementia: a Mendelian randomization study.BMC neurology · 2026Article
- Burden of Stroke in China From 1990 to 2023: Analysis From the Global Burden of Disease Study 2023.Online journal of public health informatics · 2026Article
- Denture use is associated with a higher risk of cholelithiasis: a prospective cohort study.BMC oral health · 2026Article
- Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke.Journal of the American Heart Association · 2026Article
- Vitamin D and vitamin D receptor polymorphisms modify cardiovascular outcomes in asthma: a prospective cohort study based on the UK Biobank.BMC pulmonary medicine · 2026Article
- Chronotype, Life's Essential 8, and Risk of Cardiovascular Disease: A Prospective Cohort Study in UK Biobank.Journal of the American Heart Association · 2026Article
- The association between childhood body size, adulthood lifestyle, and risk of 50 health conditions.Communications medicine · 2026Article
- Association between Accelerometer-derived Physical Activity-related Metabolic Signature and Stroke: A Cohort Study from UK Biobank.The journal of nutrition, health & aging · 2026Article
- Biological ageing, diet quality, and stroke: evidence from two population-based studies and an exploratory hospital-based Chinese cross-sectional dataset.Frontiers in nutrition · 2026Article
- Exposure to outdoor artificial light at night is associated with a higher risk of ulcerative colitis: a prospective cohort study from the UK Biobank.Frontiers in public health · 2026Article
- EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging.npj aging · 2025Article
- Risk factor control in relation to mortality and life expectancy among people with type 2 diabetes: results from 3 nationwide cohort studies.Military Medical Research · 2025Article
- Prioritizing acquired risk factors of atherosclerotic cardiovascular disease according to genetic predisposition: implications for precise prevention.BMC cardiovascular disorders · 2025Article
107 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke.
designProspective population based cohort study.
settingUK Biobank Study, UK.
participants306 473 men and women, aged 40-73 years, recruited between 2006 and 2010.
main outcome measureHazard ratios for a first stroke, estimated using Cox regression. A polygenic risk score of 90 single nucleotide polymorphisms previously associated with stroke was constructed at P<1×10
resultsDuring a median follow-up of 7.1 years (2 138 443 person years), 2077 incident strokes (1541 ischaemic stroke, 287 intracerebral haemorrhage, and 249 subarachnoid haemorrhage) were ascertained. The risk of incident stroke was 35% higher among those at high genetic risk (top third of polygenic score) compared with those at low genetic risk (bottom third): hazard ratio 1.35 (95% confidence interval 1.21 to 1.50), P=3.9×10
conclusionIn this cohort study, genetic and lifestyle factors were independently associated with incident stroke. These results emphasise the benefit of entire populations adhering to a healthy lifestyle, independent of genetic risk.
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