ArticleeLife2018
Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis.Cell death and differentiation · 2026Article
- Targeting enolase isoenzyme 2 enables precision glycolysis inhibition in VHL-mutant renal cell carcinoma.Cell death & disease · 2026Article
- Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer.Cell communication and signaling : CCS · 2026Article
- VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.Nature communications · 2026Article
- IFI44 Promotes Clear Cell Renal Cell Carcinoma Progression via PRDX1 and Predicts Poor Prognosis.Research (Washington, D.C.) · 2026Article
- Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway.International journal of biological sciences · 2025Article
- Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma.Cancer research · 2024Article
- VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway.iScience · 2024Article
- The emerging roles of histone demethylases in cancers.Cancer metastasis reviews · 2024Review
- Genetic and Epigenetic Characteristics in Isolated Pancreatic Metastases of Clear-Cell Renal Cell Carcinoma.International journal of molecular sciences · 2023Review
- Homologous recombination deficiency serves as a prognostic biomarker in clear cell renal cell carcinoma.Experimental and therapeutic medicine · 2023Article
- Essential role of bromodomain proteins in renal cell carcinoma (Review).Molecular medicine reports · 2023Review
- PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma.Nature cell biology · 2023Article
- Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma.Frontiers in oncology · 2023Article
- Article
- Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCC.Data in brief · 2022Article
- The convergence of tumor suppressors on the type I interferon pathway in clear cell renal cell carcinoma and its therapeutic implications.American journal of physiology. Cell physiology · 2022Review
- BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.Cancer letters · 2022Article
- Review
- The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis.Cancers · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
21 authors at 7 institutions in 2 countries.
Lili Liao *Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Zongzhi Z Liu *Department of Pathology, Yale University, Connecticut, United States.
Lauren Langbein *Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.ORCID http://orcid.org/0000-0002-3007-5287
Weijia Cai *Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Eun-Ah Cho *Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Jie NaDepartment of Health Sciences Research, Mayo Clinic, Minnesota, United States.
Xiaohua NiuDepartment of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wei JiangDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Zhijiu ZhongSidney Kimmel Cancer Center, Thomas Jefferson University, Pennsylvania, United States.
Wesley L CaiDepartment of Pathology, Yale University, Connecticut, United States.
Geetha JagannathanDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Essel DulaimiFox Chase Cancer Center, Pennsylvania, United States.
Joseph R TestaFox Chase Cancer Center, Pennsylvania, United States.
Robert G UzzoFox Chase Cancer Center, Pennsylvania, United States.
Yuxin WangDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio, United States.
George R StarkDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio, United States.
Jianxin SunDepartment of Medicine, Thomas Jefferson University, Pennsylvania, United States.
Stephen PeiperDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.
Yaomin XuDepartment of Biostatistics, Vanderbilt University Medical Center, Tennessee, United States.ORCID http://orcid.org/0000-0002-3752-4006
Qin YanDepartment of Pathology, Yale University, Connecticut, United States.ORCID https://orcid.org/0000-0003-4077-453X
Haifeng YangDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States.ORCID http://orcid.org/0000-0002-0892-9055
Thomas Jefferson University · USFox Chase Cancer Center · USCleveland Clinic Lerner College of Medicine · USYale University · USMayo Clinic in Florida · USSun Yat-sen University · CNVanderbilt University Medical Center · US
Funding
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI DANIEL P SILVER · 1995 to 2026
$94.8MRegulation of Endothelial Nitric Oxide Synthase mRNA StabilityR01HL103869 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SUN, JIANXIN · 2010 to 2020
$3.5MInvestigation of HIF-dependent and -independent tumor suppressor functions of VHLR01CA155015 · NCI · THOMAS JEFFERSON UNIVERSITY · PI YANG, HAIFENG · 2012 to 2016
$1.6MNur77 Suppresses Sepsis-Induced Endothelial DysfunctionR01GM123047 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI SUN, JIANXIN · 2017 to 2020
$1.2MNCI NIH HHS P30 CA056036NCI NIH HHS P30CA056036NCI NIH HHS R01 CA155015NHLBI NIH HHS R01 HL103869NIGMS NIH HHS R01 GM123047
Abstract
Whereas
Indexed as
Gene Expression RegulationGenes, Tumor SuppressorAnimalsBasic Helix-Loop-Helix ProteinsCarcinoma, Renal CellCell Line, TumorDisease Models, AnimalEndothelial PAS Domain-Containing Protein 1Feedback, PhysiologicalGene Expression ProfilingHeterograftsHumansInterferon-Stimulated Gene Factor 3, gamma SubunitKidney NeoplasmsMice, NudeNeoplasm TransplantationBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Interferon-Stimulated Gene Factor 3, gamma SubunitIRF9 protein, humanVHL protein, humanVon Hippel-Lindau Tumor Suppressor ProteinBAP1cancer biologychromosomesgene expressionhumanISGF3KDM5Ckidney cancerPBRM1VHL
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.