ArticleeLife2018
INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.
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Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.bioRxiv : the preprint server for biology · 2026Article
- Exploring the omnigenic architecture of selected complex traits.American journal of human genetics · 2025Article
- Gene-environment interactions shape the host-microbial interface in inflammatory bowel disease.Nature immunology · 2025Review
- The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation-Ubiquitylation Crosstalk of HMGA2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells.bioRxiv : the preprint server for biology · 2025Article
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- Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease.International journal of molecular sciences · 2023Review
- Paracellular permeability and tight junction regulation in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Value of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease.Gastroenterology · 2022Review
- Principles and functions of condensate modifying drugs.Frontiers in molecular biosciences · 2022Review
- Small-molecule modulators of INAVA cytosolic condensate and cell-cell junction assemblies.The Journal of cell biology · 2021Article
- Actin cytoskeleton dynamics during mucosal inflammation: a view from broken epithelial barriers.Current opinion in physiology · 2021Article
- Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and Immunoregulation in Synovial Fibroblasts.Frontiers in immunology · 2021Article
- Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening.BMC medical genomics · 2020Article
- Article
- Peptidoglycan Metabolite Photoaffinity Reporters Reveal Direct Binding to Intracellular Pattern Recognition Receptors and Arf GTPases.ACS chemical biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Phi LuongDivision of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.ORCID http://orcid.org/0000-0003-1642-7415
Matija HedlDepartment of Medicine, Yale University, New Haven, United States.
Jie YanDepartment of Medicine, Yale University, New Haven, United States.
Tao ZuoDivision of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.
Tian-Min FuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Xiaomo JiangNovartis Institutes for Biomedical Research, Cambridge, United States.
Jay R ThiagarajahDivision of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.
Steen H HansenDivision of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.
Cammie F LesserDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Cambridge, United States.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.
Clara AbrahamDepartment of Medicine, Yale University, New Haven, United States.
Wayne I LencerDivision of Gastroenterology, Nutrition and Hepatology, Boston Children's Hospital, Boston, United States.ORCID http://orcid.org/0000-0001-7346-2730
Boston Children's Hospital · USYale University · USHarvard University · USNovartis (United States) · US
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MMechanism of action for the epithelial-specific ER stress sensor IRE1β in regulating intestinal homeostasis and host defenseR01DK048106 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI WAYNE I LENCER · 1993 to 2026
$9.6MTraining Program in Newborn and Developmental DiseasesT32HD007466 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI KOUREMBANAS, STELLA · 1994 to 2016
$8.0MIntestinal Disease-enterocyte toxin interactionR37DK048106 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LENCER, WAYNE I · 2011 to 2020
$7.0MFunctional outcomes of inflammatory bowel disease associated variantsR01DK099097 · NIDDK · YALE UNIVERSITY · PI CLARA ABRAHAM · 2013 to 2026
$7.0MNLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress SensingR01AI124491 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2016 to 2025
$5.1Mp190 RhoGAP signaling in epithelial oncogenesisR01CA205158 · NCI · BOSTON CHILDREN'S HOSPITAL · PI HANSEN, STEEN HENNING · 2017 to 2021
$2.0MFcRn-dependent sorting of IgG and IgG-opsinized antigens by epithelial cellsR01DK084424 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LENCER, WAYNE I · 2009 to 2013
$1.9MNCI NIH HHS R01 CA205158NIAID NIH HHS R01 AI124491NICHD NIH HHS T32 HD007466NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK048106NIDDK NIH HHS R01 DK084424NIDDK NIH HHS R01 DK099097NIDDK NIH HHS R37 DK048106NIH HHS DK048106NIH HHS DK084424NIH HHS DK099097NIH HHS P30 DK034854NIH HHS T32HD007466
Abstract
Homeostasis at mucosal surfaces requires cross-talk between the environment and barrier epithelial cells. Disruption of barrier function typifies mucosal disease. Here we elucidate a bifunctional role in coordinating this cross-talk for the inflammatory bowel disease risk-gene
Indexed as
Signal TransductionActinsCarrier ProteinsCell MembraneEpitheliumGreen Fluorescent ProteinsGTPase-Activating ProteinsHumansInflammationIntercellular JunctionsInterleukin-1betaMacrophagesMucous MembraneProtein BindingProtein DomainsProtein IsoformsActinsCarrier Proteinscytohesin-2Green Fluorescent ProteinsGTPase-Activating ProteinsINAVA protein, humanInterleukin-1betaProtein IsoformsTNF Receptor-Associated Factor 6actin assemblyARNObiochemistrycell biologychemical biologyepithelial barrierhumanIL-1binflammatory bowel diseaseTRAF6
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.