ArticleBMC infectious diseases2018
Rising rates of injection drug use associated infective endocarditis in Virginia with missed opportunities for addiction treatment referral: a retrospective cohort study.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Long term surgical outcomes for infective endocarditis in people who inject drugs: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Drug Use and Postoperative Mortality Following Valve Surgery for Infective Endocarditis: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Impact of Medication for Opioid Use Disorder on Patient Directed Discharge Among Patients with Opioid Use Disorder.Journal of general internal medicine · 2026Article
- Insurance Status and Quality of Care in Infective Endocarditis: A National Analysis of Disparities in Length of Stay, Discharge, and Mortality.Journal of clinical medicine · 2026Article
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- Outcomes and financial comparison of percutaneous debulking versus surgical management of tricuspid endocarditis.Journal of cardiothoracic surgery · 2026Article
- Infective Endocarditis Hospitalizations in Kentucky, 2008-2018: Spatial and Temporal Trends.Journal of Appalachian health · 2026Article
- Clinical Impact of an Expanded MOUD Access Initiative for Patients Hospitalized With Infections From Intravenous Opioid Use.American journal of medicine open · 2025Article
- Article
- Inpatient addiction care is associated with increased vaccinations, medication for opioid use disorder and naloxone prescribing among patients with infective endocarditis in a rural state.Addiction science & clinical practice · 2025Article
- An Assessment of C-Reactive Protein and Erythrocyte Sedimentation Rate in Ruling Out Acute Infectious Spinal Pathology in Emergency Department Patients: A Retrospective Cohort Study.Journal of the American College of Emergency Physicians open · 2025Article
- Injection-Related Infections and Self-treatment Practices Among People Who Inject Drugs in Rural Appalachia.Open forum infectious diseases · 2025Article
- Exploring the value and acceptability of a patient navigator program for people who inject drugs and are hospitalized for bacterial infections: patients', community organization and healthcare workers' perspectives.BMC infectious diseases · 2025Article
- The rising cost of infective endocarditis in West Virginia.Epidemiology and infection · 2024Article
- Long-term Risk of Serious Infections and Mortality Among Patients Surviving Drug Use-Associated Infective Endocarditis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Clinical characteristics and risk factors for right-sided infective endocarditis in Korea: a 12-year retrospective cohort study.Scientific reports · 2024Article
- Epidemiology of acute infections in people who inject drugs in Australia.Drug and alcohol review · 2024Review
- Changing the High-Risk Behaviors of Injecting Drug Users in Iran: Application Theory of Planned Behavior.TheScientificWorldJournal · 2024Article
- Evidence of telescoping in females across two decades of US treatment admissions for injection drug use: 2000-2020.Drug and alcohol dependence reports · 2023Article
- Beyond HIV: An urgent need for a syndemic and gender-based approach in the Prairie provinces in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInjection drug use (IDU) is a growing public health threat in Virginia, though there is limited knowledge of related morbidity. The purpose of this study was to describe the temporal, geographic and clinical trends and characteristics of infective endocarditis associated with IDU (IDU-IE) and to identify opportunities for better-quality care of people who inject drugs (PWID).
methodsWe reviewed charts for all admissions coded for both IE and drug use disorders at the University of Virginia Medical Center (UVA) from January 2000 to July 2016. A random sample of 30 admissions coded for IE per year were reviewed to evaluate temporal trends in the proportion of IDU associated IE cases.
resultsThere were a total of 76 patients with IDU-IE during the study period, 7.54-fold increase (prevalence ratio: 8.54, 95% CI 3.70-19.72) from 2000 to 2016. The proportion of IE that was IDU-associated increased by nearly 10% each year (prevalence ratio of IDU per year: 1.09, 95% CI: 1.05-1.14). Patients with IDU-IE had longer hospital stays [median days (interquartile range); IDU-IE, 17 (10-29); non-IDU-IE, 10 (6-18); p-value = 0.001] with almost twice the cost of admission as those without IDU [median (interquartile range); IDU-IE, $47,899 ($24,578-78,144); non-IDU-IE, $26,460 ($10,220-60,059); p-value = 0.001]. In 52% of cases there was no documentation of any discussion regarding addiction treatment.
conclusionIDU-IE is a severe infection that leads to significant morbidity and healthcare related costs. IDU-IE rates are increasing and will likely continue to do so without targeted interventions to help PWID. The diagnosis and treatment of IDU-IE provides an opportunity for the delivery of addiction treatment, counseling, and harm reduction strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.