Evidence map›Paper›PMID 30355253›Full record

ReviewCirculation research2018

Cerebrovascular Alterations in Alzheimer Disease.

Costantino Iadecola, Rebecca F Gottesman

Abstract readReview
In one paragraph

Review in Circulation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed.

  1. Trial
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  16. Systemic Piezo1 activation improves cerebrovascular function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Cerebrovascular morphology: Insights into normal variations, aging effects and disease implications.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Costantino IadecolaFrom the Weill Cornell Medicine, Feil Family Brain and Mind Research Institute, New York (C.I.).
Rebecca F GottesmanDepartment of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD (R.F.G.).

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Overexpression of the amyloid precursor protein and cerebrovascular regulationR01NS037853 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Costantino Iadecola · 1998 to 2026
$10.6M
The ARIC-PET Amyloid Imaging StudyR01AG040282 · NIA · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF, SPIRA, ADAM PETER · 2011 to 2021
$7.1M
Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskR01NS095441 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2025
$4.7M
The ARIC study of midlife sleep and late-life brain amyloidRF1AG050745 · NIA · JOHNS HOPKINS UNIVERSITY · PI SPIRA, ADAM PETER · 2016 to 2016
$3.8M
ApoE4 and mechanisms of diffuse white matter injuryR01NS100447 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2020
$3.5M
Hypertension and neurovascular dysfunctionR37NS089323 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2015 to 2021
$3.1M
Neuroepidemiology of the vascular contribution to cognitive impairment and Alzheimer's diseaseK24AG052573 · NIA · JOHNS HOPKINS UNIVERSITY · PI GOTTESMAN, REBECCA F · 2016 to 2020
$803k
NIA NIH HHS K24 AG052573NIA NIH HHS P50 AG005146NIA NIH HHS R01 AG040282NIA NIH HHS RF1 AG050745NINDS NIH HHS R01 NS037853NINDS NIH HHS R01 NS095441NINDS NIH HHS R01 NS100447NINDS NIH HHS R37 NS089323
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAnimalsCerebrovascular DisordersHumansAlzheimer diseaseblood-brain barrierdementianeuronsrisk factors

Identifiers

PMID30355253
PMCPMC6214471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.