Evidence map›Paper›PMID 30355114›Full record

ArticleStroke2018

Clinical Outcomes and Neuroimaging Profiles in Nondisabled Patients With Anticoagulant-Related Intracerebral Hemorrhage.

Vasileios-Arsenios Lioutas, Nitin Goyal, Aristeidis H Katsanos, Christos Krogias, Ramin Zand, Vijay K Sharma, Panayiotis Varelas, Konark Malhotra, Maurizio Paciaroni, Aboubakar Sharaf and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Is a high chest CT severity score a risk factor for an increased incidence of long-term neuroimaging findings after COVID-19?Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  10. Article
  11. Article
  12. COVID-19: Neuroimaging Features of a Pandemic.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021
    Review
  13. Review
  14. Article
  15. Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed.Annals of clinical and translational neurology · 2019
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Vasileios-Arsenios LioutasFrom the Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L., M.H.S.).
Nitin GoyalDepartment of Neurology, University of Tennessee Health Science Center, Memphis (N.G., A.P., A.K., A.V.A., G.T.).
Aristeidis H KatsanosSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece (A.H.K., G.T.).
Christos KrogiasDepartment of Neurology, St Josef-Hospital, Ruhr University of Bochum, Germany (C.K., C.S.).
Ramin ZandDepartment of Neurology, Geisinger Medical Center, Danville, PA (R.Z., A.K.).
Vijay K SharmaDivision of Neurology, Yong Loo Lin School of Medicine, National University of Singapore (V.K.S.).
Panayiotis VarelasDepartment of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.M., P.D.M.).
Konark MalhotraDepartment of Neurology, West Virginia University Charleston Division (K.M.).
Maurizio PaciaroniStroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P.).
Aboubakar SharafDepartment of Neurology, Essentia Health-Duluth Clinic, MN (A.S.).
Jason ChangDepartment of Critical Care Medicine, MedStar Washington Hospital Center, DC (J.C.).
Theodore KarapanayiotidesSecond Department of Neurology, AHEPA University Hospital, Aristotelian University of Thessaloniki, Greece (T.K.).
Odysseas KargiotisAcute Stroke Unit, Metropolitan Hospital, Piraeus, Greece (O.K.).
Alexandra PappaDepartment of Neurology, University of Tennessee Health Science Center, Memphis (N.G., A.P., A.K., A.V.A., G.T.).
Jeffrey MaiDepartment of Neurosurgery Georgetown University, Washington, DC (J.M.).
Abhi Pandhi
Christoph SchroederDepartment of Neurology, St Josef-Hospital, Ruhr University of Bochum, Germany (C.K., C.S.).
Argyrios TsantesLaboratory of Haematology and Blood Bank Unit, "Attikon" Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece (A.T.).
Chandan MehtaDepartment of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.M., P.D.M.).
Ali KerroDepartment of Neurology, University of Tennessee Health Science Center, Memphis (N.G., A.P., A.K., A.V.A., G.T.).
Ayesha KhanDepartment of Neurology, Geisinger Medical Center, Danville, PA (R.Z., A.K.).
Panayiotis D MitsiasDepartment of Neurology, Henry Ford Hospital, Detroit, MI (P.V., C.M., P.D.M.).
Magdy H SelimFrom the Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L., M.H.S.).
Andrei V AlexandrovDepartment of Neurology, University of Tennessee Health Science Center, Memphis (N.G., A.P., A.K., A.V.A., G.T.).
Georgios TsivgoulisDepartment of Neurology, University of Tennessee Health Science Center, Memphis (N.G., A.P., A.K., A.V.A., G.T.).

Funding

Futility Study of Deferoxamine Mesylate in Intracerebral Hemorrhage (i-DEF)U01NS074425 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SELIM, MAGDY H · 2012 to 2016
$8.7M
NINDS NIH HHS U01 NS074425
6 · The paper itself

Abstract

Background and Purpose- The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K antagonist (VKA)-related intracerebral hemorrhage (ICH). Methods- Prospective 12-month observational study in 15 tertiary stroke centers in the United States, Europe, and Asia. Consecutive patients with premorbid modified Rankin Scale score of <2 with acute nontraumatic anticoagulant-related ICH divided into 2 groups according to the type of anticoagulant: NOAC versus VKA. We recorded baseline ICH volume, significant hematoma expansion (absolute [12.5 mL] or relative [>33%] increase), neurological severity measured by National Institutes of Health Stroke Scale score, 90-day mortality, and functional status (modified Rankin Scale score). Results- Our cohort comprised 196 patients, 62 NOAC related (mean age, 75.0±11.4 years; 54.8% men) and 134 VKA related (mean age, 72.3±10.5; 73.1% men). There were no differences in vascular comorbidities, antiplatelet, and statin use; NOAC-related ICH patients had lower median baseline hematoma volume (13.8 [2.5-37.6] versus 19.5 [6.6-52.0] mL; P=0.026) and were less likely to have severe neurological deficits (National Institutes of Health Stroke Scale score of >10 points) on admission (37% versus 55.3%, P=0.025). VKA-ICH were more likely to have significant hematoma expansion (37.4% versus 17%, P=0.008). NOAC pretreatment was independently associated with smaller baseline hematoma volume (standardized linear regression coefficient:-0.415 [95% CI, -0.780 to -0.051]) resulting in lower likelihood of severe neurological deficit (odds ratio, 0.44; 95% CI, 0.22-0.85) in multivariable-adjusted models. Conclusions- Patients with NOAC-related ICH have smaller baseline hematoma volumes and lower odds of severe neurological deficit compared with VKA-related ICH. These findings are important for practicing clinicians making anticoagulation choices.

Indexed as

NeuroimagingAdministration, OralAgedAged, 80 and overAnticoagulantsCerebral HemorrhageFemaleHematomaHumansMaleMiddle AgedProspective StudiesTreatment OutcomeVitamin KWarfarinAnticoagulantsVitamin KWarfarinanticoagulantsbraindabigatranrivaroxabanwarfarin

Identifiers

PMID30355114
PMCPMC6386175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.