ArticleStroke2018
Integration of Computed Tomographic Angiography Spot Sign and Noncontrast Computed Tomographic Hypodensities to Predict Hematoma Expansion.
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Review
- Co-localization of NCCT hypodensity and CTA spot sign predicts substantial intracerebral hematoma expansion: The Black-&-White sign.European stroke journal · 2025Article
- Article
- Blend Sign and Haemorrhage Location and Volume Predict Late Recurrence and Mortality in Intracerebral Haemorrhage Patients.Journal of clinical medicine · 2023Article
- Derivation and validation of three intracerebral hemorrhage expansion scores using different CT modalities.European radiology · 2023Article
- Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion.Stroke · 2023Article
- Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review.Frontiers in neurology · 2023Review
- Article
- The Added Value of Intraventricular Hemorrhage on the Radiomics Analysis for the Prediction of Hematoma Expansion of Spontaneous Intracerebral Hemorrhage.Diagnostics (Basel, Switzerland) · 2022Article
- Intracerebral hemorrhage markers on non-contrast computed tomography as predictors of the dynamic spot sign on CT perfusion and associations with hematoma expansion and outcome.Neuroradiology · 2022Article
- External ventricular drain placement is associated with lower mortality after intracerebral hemorrhage with intraventricular hemorrhage.International journal of emergency medicine · 2022Article
- Non-contrast CT markers of intracerebral hematoma expansion: a reliability study.European radiology · 2022Article
- Machine learning prediction of hematoma expansion in acute intracerebral hemorrhage.Scientific reports · 2022Article
- Computed Tomography Imaging Predictors of Intracerebral Hemorrhage Expansion.Current neurology and neuroscience reports · 2021Review
- Neuroimaging of Acute Intracerebral Hemorrhage.Journal of clinical medicine · 2021Review
- Lack of racial and ethnic-based differences in acute care delivery in intracerebral hemorrhage.International journal of emergency medicine · 2021Article
- Smoking Status Affects the Association Between Hematoma Heterogeneity and Hematoma Expansion.World neurosurgery: X · 2021Article
- Association of Serum Dystroglycan, MMP-2/9 and AQP-4 with Haematoma Expansion in Patients with Intracerebral Haemorrhage.Neuropsychiatric disease and treatment · 2021Article
- Validation and Comparison of Noncontrast CT Scores to Predict Intracerebral Hemorrhage Expansion.Neurocritical care · 2020Article
- Correlation between Spot Sign and Intracranial Hemorrhage Expansion on Dual-Phase CT Angiography.Diagnostics (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Background and Purpose- Noncontrast computed tomographic (CT) hypodensities represent an alternative to the CT angiography spot sign (SS) to predict intracerebral hemorrhage (ICH) expansion. However, previous studies suggested that these markers predicted hematoma expansion independently from each other. We investigated whether the integration of SS and hypodensity (HD) improved the stratification of ICH expansion risk. Methods- A single-center cohort of consecutive patients with ICH was retrospectively analyzed. Patients with available CT angiography, baseline, and follow-up noncontrast CT images available were included. Trained readers reviewed all the images for SS and HD presence, and the study population was classified into 4 groups: SS and HD negative (SS-HD-), SS positive only (SS+HD-), HD positive only (SS-HD+), and SS and HD positive (SS+HD+). ICH expansion was defined as hematoma growth >33% or >6 mL. The association between SS and HD presence and ICH expansion was investigated with multivariable logistic regression. Results- A total of 745 subjects qualified for the analysis (median age, 73 years; 54.1% men). The rates of ICH expansion were 9.3% in SS-HD-, 25.8% in SS+HD-, 27.4% in SS-HD+, and 55.6% in SS+HD+ patients ( P<0.001). After adjustment for potential confounders and keeping SS-HD- subjects as reference, the risk of ICH expansion was increased in SS+HD- and SS-HD+ patients (odds ratio, 2.93, P=0.002 and odds ratio, 3.02, P<0.001, respectively). SS+HD+ subjects had the highest risk of hematoma growth (odds ratio, 9.50; P<0.001). Conclusions- Integration of SS and HD improves the stratification of hematoma growth risk and may help the selection of patients with ICH for antiexpansion treatment in clinical trials.
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Registered trials
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