ArticleAutophagy2019
Inflammatory-dependent Sting activation induces antiviral autophagy to limit zika virus in the Drosophila brain.
Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Zika virus: unraveling the complex interplay between viral pathogenesis and host immune defenses.Virology journal · 2026Review
- Article
- Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity.Veterinary research · 2025Review
- The regulation of cGAS-STING signaling by RNA virus-derived components.Virology journal · 2024Review
- Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration.Cells · 2024Review
- The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy.Frontiers in immunology · 2024Review
- Review
- Article
- The role of autophagy in viral infections.Journal of biomedical science · 2023Review
- Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation.Cells · 2022Review
- Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.Frontiers in immunology · 2022Article
- How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Autophagy.International journal of molecular sciences · 2021Review
- Autophagy in Viral Infection and Pathogenesis.Frontiers in cell and developmental biology · 2021Review
- Sending Out Alarms: A Perspective on Intercellular Communications in Insect Antiviral Immune Response.Frontiers in immunology · 2021Review
- Innate Immune DNA Sensing of Flaviviruses.Viruses · 2020Review
- Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15.Cell death and differentiation · 2020Article
- Article
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2 authors at 1 institution in 1 country.
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Abstract
Incidences of congenital syndrome associated with maternal zika virus (ZIKV) infection during pregnancy are well documented; however, the cellular and molecular mechanisms by which ZIKV infection causes these devastating fetal pathologies are still under active investigation. ZIKV is a member of the flavivirus family and is mainly transmitted to human hosts through Aedes mosquito vectors. However, in vivo models for the neurological tropism of the virus and the arthropod vector have been lacking. A recent study published in Cell Host & Microbe from Dr. Sara Cherry's lab investigates both of these key aspects of the ZIKV infectious life cycle. Liu et al. demonstrate how inflammatory activated Sting/dSTING-dependent antiviral macroautophagy/autophagy is sufficient to restrict ZIKV infection in the Drosophila melanogaster brain. Additionally, this study provides further evidence for the ancestral function of autophagy in protecting host cells from viral invaders. Abbreviations: AGO2: Argonaute 2; ATG: autophagy-related; Dcr-2: Dicer-2; DptA/Dipt: Diptericin A; Drs: Drosomycin; DCV: Drosophila C virus; IMD: immune-deficiency; qRT-PCR: quantitative real-time PCR; Rel/NF-κB: Relish; RNAi: RNA interference; ZIKV: zika virus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.