ArticleHypertension (Dallas, Tex. : 1979)2018
Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.
Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Precision approaches to paediatric hypertension: linking pathophysiology to therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- New Aspects of Understanding Individual Magnetosensitivity to Geomagnetic Storms.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Exercise blood pressure, cardiorespiratory fitness, fatness and cardiovascular risk in children and adolescents.Frontiers in public health · 2024Review
- Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2023Article
- High-output Cardiac Failure: A Forgotten Phenotype in Clinical Practice.Current cardiology reviews · 2022Review
- Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women.Diabetology international · 2022Article
- Haemodynamics of Hypertension in Children.Current hypertension reports · 2020Review
- The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence.Scandinavian journal of medicine & science in sports · 2020Observational
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8 authors at 4 institutions in 1 country.
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Abstract
Unlike in older people, it has been suggested that elevated blood pressure (BP) in young people is because of high cardiac output accompanied by normal total peripheral resistance (TPR)-a hyperkinetic/hyperdynamic circulation. We investigated this in a large, United Kingdom-based birth cohort of adolescents. The study was conducted on 2091 17-year-old participants in the ALSPAC (Avon Longitudinal Study of Parents and Children)-a prospective population-based birth cohort study. BP measurement and echocardiography were performed, and heart rate (HR), stroke volume (SV), and TPR were calculated. Data are means (SD). Higher quintiles of systolic BP were associated with higher SV, higher HR, and higher TPR. The proportional contribution made by SV, HR, and TPR to mean arterial pressure differed little by systolic BP quintile (SV [32%-34%], HR [25%-29%], and TPR [39%-41%]). Higher BP is attributable to a combination of higher cardiac output (ie, SV×HR) and higher TPR in a population-based sample of adolescents. There is no evidence of a disproportionate contribution from elevated cardiac output at higher BP levels.
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Registered trials
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