Evidence map›Paper›PMID 30354808›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Lingli Li, En Yin Lai, Zaiming Luo, Glenn Solis, Margarida Mendonca, Kathy K Griendling, Anton Wellstein, William J Welch, Christopher S Wilcox

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. High NaBiomedicines · 2021
    Review
  9. Oxidative Stress and Hypertension.Circulation research · 2021
    Review
  10. Article
  11. Article
  12. [Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  13. Article
  14. Endothelial prostaglandin DJournal of the renin-angiotensin-aldosterone system : JRAAS
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lingli LiFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
En Yin LaiFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Zaiming LuoFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Glenn SolisFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Margarida MendoncaFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Kathy K GriendlingDivision of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA (K.K.G.).
Anton WellsteinLombardi Cancer Center, Georgetown University, Washington, DC (A.W.).
William J WelchFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Christopher S WilcoxFrom the Division of Nephrology and Hypertension, and Hypertension Research Center, Georgetown University, Washington, DC (L.L., E.Y.L., Z.L., G.S., M.M., W.J.W., C.S.W.).
Georgetown University · USZhejiang University · CN

Funding

Renal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8M
T cell triggering events and hypertensionP01HL095070 · NHLBI · EMORY UNIVERSITY · PI JO, HANJOONG · 2009 to 2019
$20.5M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER37DK036079 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 2003 to 2012
$5.2M
NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUSR01DK049870 · NIDDK · GEORGETOWN UNIVERSITY · PI WILCOX, CHRISTOPHER S · 1994 to 2014
$4.6M
Regulation of Renal Function and BP by ThromboxaneR01DK109272 · NIDDK · GEORGETOWN UNIVERSITY · PI WELCH, WILLIAM J, WILCOX, CHRISTOPHER S · 2016 to 2019
$1.4M
REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANER01DK036079 · NIDDK · UNIVERSITY OF FLORIDA · PI WILCOX, CHRISTOPHER S · 1986 to 2002
$830k
NHLBI NIH HHS P01 HL068686NHLBI NIH HHS P01 HL095070NIDDK NIH HHS R01 DK036079NIDDK NIH HHS R01 DK049870NIDDK NIH HHS R01 DK109272NIDDK NIH HHS R37 DK036079
6 · The paper itself

Abstract

High salt, Ang II (angiotensin II), and reactive oxygen species enhance progression of chronic kidney disease. We tested the hypothesis that a high salt intake generates specific reactive oxygen species to enhance Ang II contractions of afferent arterioles from mice with reduced renal mass (RRM). C57BL/6 mice were subjected to surgical RRM or sham operations and received 6% or 0.4% NaCl salt diet for 3 months. Ang II contractions were measured in perfused afferent arterioles and superoxide (O

Indexed as

Angiotensin IIAnimalsArteriolesCatalaseHydrogen PeroxideKidneyKidney GlomerulusMiceReactive Oxygen SpeciesSodium Chloride, DietarySuperoxidesAngiotensin IICatalaseHydrogen PeroxideReactive Oxygen SpeciesSodium Chloride, DietarySuperoxidesangiotensin IIhydrogen peroxidereactive oxygen speciessuperoxidestempol

Identifiers

PMID30354808
PMCPMC6221452
OpenAlexW2896209608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.