ArticleHypertension (Dallas, Tex. : 1979)2018
Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women.
Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Supramaximal high-intensity interval training improves heart rate variability in older adults: A randomized controlled trial.Physiological reports · 2026Trial
- Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2026Review
- Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.American journal of physiology. Heart and circulatory physiology · 2026Article
- Heart Rate Variability Moderates the Association Between Trait Anxiety and Sympathetic Nerve Activity in Humans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Exercise pills for cardiometabolic health cannot mimic the exercise milieu.Trends in endocrinology and metabolism: TEM · 2026Review
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Acute exogenous oestradiol augments endothelial and smooth muscle vasodilatory responsiveness in premenopausal but not postmenopausal females.The Journal of physiology · 2025Article
- Vascular limitations in blood pressure regulation with age in women: Insights from exercise and acute cardioselective β-blockade.Experimental physiology · 2025Article
- Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis.Osteoarthritis and cartilage open · 2024Article
- Understanding the Complexity of Hypertension with Sarcopenia by Scientometric Analysis.Journal of multidisciplinary healthcare · 2024Article
- Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2024Article
- Cardiac psychophysiological tuning to socioaffective content is disrupted in aged rhesus monkeys (Macaca mulatta).Psychophysiology · 2024Article
- Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea.International journal of molecular sciences · 2023Review
- Long-Term Visit-To-Visit Blood Pressure Variability and Risk of Diabetes Mellitus in Chinese Population: A Retrospective Population-Based Study.International journal of public health · 2023Article
- Neuromodulation as a Potential Disease-Modifying Therapy for Osteoarthritis.Current rheumatology reports · 2023Review
- Article
- Device-based neuromodulation for cardiovascular diseases and patient' s age.Journal of geriatric cardiology : JGC · 2022Article
- Sports activities at a young age decrease hypertension risk-The J-FitPhysiological reports · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Autonomic support of blood pressure increases with age in humans. Large differences exist in the dose of trimethaphan (TMP) required for ganglionic blockade in young and older women. We asked whether differences in the dose of TMP required to achieve ganglionic blockade are because of differences in the relative contributions of the sympathetic and parasympathetic nervous system in control of blood pressure with age. Muscle sympathetic nerve activity (microneurography, peroneal nerve), heart rate (HR), and blood pressure were recorded before and during incremental doses of TMP camsylate until ganglionic blockade was achieved (absence of muscle sympathetic nerve activity and <5-bpm increase in HR during a valsalva maneuver; final TMP dose, 1-7 mg/min). HR variability was analyzed from the ECG waveform (WinCPRS). The dose of TMP required to achieve ganglionic blockade is positively related to basal HR variability, where women with high HR variability require a higher dose of TMP to achieve ganglionic blockade. In contrast, baseline muscle sympathetic nerve activity is inversely related with the dose of TMP required to achieve ganglionic blockade, such that women with high basal muscle sympathetic nerve activity required a lower dose of TMP. As such, the change in HR with ganglionic blockade was positively related, and the change in mean arterial pressure was inversely related, with the dose of TMP required to achieve ganglionic blockade. These data suggest loss of parasympathetic tone and increased sympathetic tone with aging contribute to the increase in blood pressure with age in women and dictate the dose of TMP that is necessary to achieve ganglionic blockade.
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