Evidence map›Paper›PMID 30354672›Full record

ArticleCirculation. Cardiovascular imaging2018

Atrial Dysfunction in Arrhythmogenic Right Ventricular Cardiomyopathy.

Tarek Zghaib, Mimount Bourfiss, Jeroen F van der Heijden, Peter Loh, Richard N Hauer, Harikrishna Tandri, Hugh Calkins, Saman Nazarian, Anneline S J M Te Riele, Stefan L Zimmerman and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tarek ZghaibDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.Z., H.T., H.C.).
Mimount BourfissDepartment of Cardiology, University Medical Center Utrecht, The Netherlands (M.B., J.F.v.d.H., P.L., R.N.H., A.S.J.M.t.R.).
Jeroen F van der HeijdenDepartment of Cardiology, University Medical Center Utrecht, The Netherlands (M.B., J.F.v.d.H., P.L., R.N.H., A.S.J.M.t.R.).
Peter LohDepartment of Cardiology, University Medical Center Utrecht, The Netherlands (M.B., J.F.v.d.H., P.L., R.N.H., A.S.J.M.t.R.).
Richard N HauerDepartment of Cardiology, University Medical Center Utrecht, The Netherlands (M.B., J.F.v.d.H., P.L., R.N.H., A.S.J.M.t.R.).
Harikrishna TandriDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.Z., H.T., H.C.).
Hugh CalkinsDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.Z., H.T., H.C.).
Saman NazarianDivision of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Anneline S J M Te RieleDepartment of Cardiology, University Medical Center Utrecht, The Netherlands (M.B., J.F.v.d.H., P.L., R.N.H., A.S.J.M.t.R.).
Stefan L ZimmermanDepartment of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD (S.L.Z.).
Birgitta K VelthuisDepartment of Radiology, University Medical Center Utrecht, The Netherlands (B.K.V.).
University Medical Center Utrecht · NLJohns Hopkins Medicine · USJohns Hopkins University · USUniversity of Pennsylvania · US

Funding

ANCILLARY STUDY OF SUBSTRATE AND INTERVENTION MECHANISMS FOR MALIGNANT ARRHYTHMIAR01HL116280 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN · 2013 to 2016
$1.2M
Applications of Magnetic Resonance for Management of Ventricular TachycardiaK23HL089333 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NAZARIAN, SAMAN · 2010 to 2014
$686k
NHLBI NIH HHS K23 HL089333NHLBI NIH HHS R01 HL116280
6 · The paper itself

Abstract

backgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy that is predominantly known to affect the ventricles. Evidence for atrial involvement remains limited. Therefore, we aimed to characterize atrial involvement in ARVC using functional cardiac magnetic resonance, define the extent of atrial size and function variation attributable to ventricular variables, and identify cardiac magnetic resonance-based predictors of atrial arrhythmias (AA) in ARVC. METHODS AND

resultsWe analyzed cine cardiac magnetic resonance images of 66 definite ARVC patients without a history of AA or severe heart failure and 24 healthy controls. Using tissue tracking, we evaluated phasic biatrial volumes, ejection fractions (EFs), peak longitudinal strain, and strain rates (SRs). The primary outcome was the occurrence of AA during 6.8 years [3.0-10.8 years] of follow-up. Compared with controls, ARVC patients had higher biatrial volumes, reduced right atrial (RA) conduit function (passive EF [RAEF

conclusionsCompared with controls, patients with ARVC were found to have enlarged atria with decreased function on functional cardiac magnetic resonance examination. RA and LA parameters predict incident AA after adjusting for clinical and ventricular characteristics which suggests atrial involvement in ARVC.

Indexed as

Atrial Function, LeftAtrial Function, RightAtrial RemodelingMagnetic Resonance Imaging, CineAdultArrhythmogenic Right Ventricular DysplasiaAtrial FibrillationAtrial FlutterCase-Control StudiesFemaleHeart AtriaHumansMaleMiddle AgedNetherlandsPredictive Value of Testsatrial fibrillationcardiomyopathyheart failurepainthrombosis

Identifiers

PMID30354672
OpenAlexW2900112410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.