ArticleCirculation. Heart failure2018
Abdominal Positioning of the Next-Generation Intra-Aortic Fluid Entrainment Pump (Aortix) Improves Cardiac Output in a Swine Model of Heart Failure.
Article in Circulation. Heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Device therapies in cardiorenal syndrome: an expert review.ESC heart failure · 2026Review
- Contemporary overview of current percutaneous mechanical circulatory support devices for advanced heart failure: a narrative review.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2026Review
- Hemodynamic performance and blood damage of the Intra-aortic pumps: A CFD-Based investigation.Medical & biological engineering & computing · 2026Article
- Percutaneous intravascular micro-axial blood pump: current state and perspective from engineering view.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2024Review
- First Description of Novel End-Organ Effects by Speed Modulation Using the Aortix™ Device.Case reports in cardiology · 2024Article
- Advances in novel devices for the treatment of heart failure.Heart failure reviews · 2023Review
- Mock circulatory loop applications for testing cardiovascular assist devices andFrontiers in physiology · 2023Review
- The Impact of a New Arterial Intravascular Pump on Aorta Hemodynamic Surrounding: A Numerical Study.Bioengineering (Basel, Switzerland) · 2022Article
- Catheter-Based Management of Heart Failure: Pathophysiology and Contemporary Data.Interventional cardiology clinics · 2022Review
- A Glimpse Into the Future of Transcatheter Interventional Heart Failure Therapies.JACC. Basic to translational science · 2022Review
- Device-based therapy for decompensated heart failure: An updated review of devices in development based on the DRIFrontiers in cardiovascular medicine · 2022Review
- The sheep as a pre-clinical model for testing intra-aortic percutaneous mechanical circulatory support devices.The International journal of artificial organs · 2021Article
- First-in-human experience with occlusion of the superior vena cava to reduce cardiac filling pressures in congestive heart failure.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2019Article
- First-in-Human Experience With the ModulHeart Device for Mechanical Circulatory Support and Renal Perfusion.Journal of the Society for Cardiovascular Angiography & InterventionsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcute heart failure refractory to medical therapy is a major cause of morbidity and mortality. The Aortix device (Procyrion Inc) is a percutaneously delivered entrainment pump positioned in the descending aorta. METHODS AND
resultsUsing the newest generation Aortix device in 8 adult male Yorkshire swine, we tested the hypothesis that positioning in the abdominal aorta may provide superior hemodynamic effects than thoracic positioning in a swine model of postinfarct left ventricular injury.Abdominal activation generated significantly larger transaortic gradients (proximal minus distal mean aortic pressures) than thoracic positioning at all pump speeds. Compared with baseline values, activation in the abdominal, not thoracic, position significantly increased cardiac output, reduced arterial elastance, and systemic vascular resistance at low speeds. Compared with baseline values, abdominal activation also increased transpulmonary pressure gradients at medium and high speed, which was driven by trends toward higher mean pulmonary artery pressure and lower pulmonary capillary wedge pressure.
conclusionsThis is the first report to determine that in contrast to thoracic positioning, abdominal positioning of the newest generation Aortix device reduces left ventricular afterload and increases cardiac output at low speeds. These findings have potentially important implications for the design of early clinical studies by suggesting that device position and speed are major determinants of improved hemodynamic efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.