ArticleArteriosclerosis, thrombosis, and vascular biology2018
LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 5% of its field
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Integrative bioinformatics frameworks for abdominal aortic aneurysm using GWAS meta-analysis, biological network construction, and structural modeling.Scientific reports · 2025Pooled it
- Graphene Quantum Dots for Glioblastoma Treatment and Detection-Systematic Review.Molecules (Basel, Switzerland) · 2025Pooled it
- Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases.Nature communications · 2021Pooled it
- Molecular Partners of Voltage-Gated Calcium Channel β and αThe Journal of membrane biology · 2026Review
- The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm.Cells · 2025Review
- LRP1 regulates asthmatic airway smooth muscle proliferation through FGF2/ERK signaling.JCI insight · 2025Article
- Tale of 2 Receptors.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Olfactory Receptors and Aortic Aneurysm: Review of Disease Pathways.Journal of clinical medicine · 2024Review
- Article
- PAI-1 Regulates the Cytoskeleton and Intrinsic Stiffness of Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Cardiometabolic benefits of fenofibrate in heart failure related to obesity and diabetes.Cardiovascular diabetology · 2024Article
- The role of PCSK9 in heart failure and other cardiovascular diseases-mechanisms of action beyond its effect on LDL cholesterol.Heart failure reviews · 2024Review
- The Integrated Bioinformatic Approach Reveals the Prognostic Significance of LRP1 Expression in Ovarian Cancer.International journal of molecular sciences · 2024Article
- Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Identification of co-diagnostic effect genes for aortic dissection and metabolic syndrome by multiple machine learning algorithms.Scientific reports · 2023Article
- LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.JCI insight · 2023Article
- LRP1 protects against excessive superior mesenteric artery remodeling by modulating angiotensin II-mediated signaling.JCI insight · 2023Article
- Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture.Circulation. Genomic and precision medicine · 2022Article
- Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease.Clinical science (London, England : 1979) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Dianaly T AuFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Zhekang YingDivision of Cardiology, Department of Medicine (Z.Y.), University of Maryland School of Medicine, Baltimore.
Erick O Hernández-OchoaDepartment of Biochemistry and Molecular Biology (E.O.H.-O., M.F.S.), University of Maryland School of Medicine, Baltimore.
William E FondrieFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Brian HamptonFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Mary MiglioriniFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Rebeca GalisteoFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Martin F SchneiderDepartment of Biochemistry and Molecular Biology (E.O.H.-O., M.F.S.), University of Maryland School of Medicine, Baltimore.
Alan DaughertyDepartment of Physiology, Saha Cardiovascular Research Center, University of Kentucky, Lexington (A.D., D.L.R.).
Debra L RateriDepartment of Physiology, Saha Cardiovascular Research Center, University of Kentucky, Lexington (A.D., D.L.R.).
Dudley K StricklandFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
Selen C MuratogluFrom the Center for Vascular and Inflammatory Diseases (D.T.A., W.E.F., B.H., M.M., R.G., D.K.S., S.C.M.), University of Maryland School of Medicine, Baltimore.
University of Maryland, Baltimore · US
Funding
Role of LDL receptor family members in protecting the vasculatureR35HL135743 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI STRICKLAND, DUDLEY K. · 2017 to 2023
$5.4MRoles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signalingR37AR055099 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHNEIDER, MARTIN F · 2012 to 2021
$3.5MAdventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9MHypothalamic Inflammation and PM2.5 Exposure-Induced Insulin ResistanceR01ES024516 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI YING, ZHEKANG · 2014 to 2018
$1.5MCryo Upgrade of UMB EM Core FacilityS10RR026870 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI HSIA, RU-CHING · 2010 to 2010
$421kRole of LRP1 in Angiotensin Signaling and Vascular RemodelingF31HL131293 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI AU, DIANALY THI · 2016 to 2017
$59kDefining a mechanism of LRP1B tumor suppression in glioblastomaF31CA213815 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FONDRIE, WILLIAM ELLIS · 2017 to 2018
$36kNCI NIH HHS F31 CA213815NCRR NIH HHS S10 RR026870NHLBI NIH HHS F31 HL131293NHLBI NIH HHS R01 HL133723NHLBI NIH HHS R35 HL135743NIAMS NIH HHS R37 AR055099NIEHS NIH HHS R01 ES024516
Abstract
Objective- Mutations affecting contractile-related proteins in the ECM (extracellular matrix), microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We reported previously that the LRP1 (low-density lipoprotein receptor-related protein 1) maintains vessel wall integrity, and smLRP1
Indexed as
Calcium SignalingVasoconstrictionActin CytoskeletonAnimalsAortaCalcium ChannelsCytoskeletal ProteinsFemaleGene Expression RegulationLow Density Lipoprotein Receptor-Related Protein-1MaleMice, KnockoutMuscle, Smooth, VascularReceptors, LDLRyanodine Receptor Calcium Release ChannelTissue Culture TechniquesCACNA2D1 protein, mouseCalcium ChannelsCytoskeletal ProteinsLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseReceptors, LDLRyanodine Receptor Calcium Release ChannelTumor Suppressor ProteinsVasoconstrictor Agentsaneurysmaortic aneurysmcalcium signalingmutationmyocytes, smooth muscle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.