Evidence map›Paper›PMID 30354100›Full record

ArticleJournal of natural products2019

Phloroglucinols from the Roots of Garcinia dauphinensis and Their Antiproliferative and Antiplasmodial Activities.

Rolly G Fuentes, Kirk C Pearce, Yongle Du, Andriamalala Rakotondrafara, Ana L Valenciano, Maria B Cassera, Vincent E Rasamison, T Daniel Crawford, David G I Kingston

Abstract read
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Constituents of the Stem Bark ofMolecules (Basel, Switzerland) · 2023
    Article
  2. Triterpene Derivatives fromPlants (Basel, Switzerland) · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rolly G FuentesDepartment of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.
Kirk C PearceDepartment of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.
Yongle DuDepartment of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.
Andriamalala RakotondrafaraDépartement d'Ethnobotanique et de Botanique , Centre National d'Application des Recherches Pharmaceutiques , Ambodivoanjo, BP 702, Antananarivo 101 , Madagascar.
Ana L ValencianoDepartment of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , Athens , Georgia 30602 , United States.
Maria B CasseraDepartment of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD) , University of Georgia , Athens , Georgia 30602 , United States.ORCID 0000-0001-6341-3169
Vincent E RasamisonCentre National d'Application des Recherches Pharmaceutiques , BP 702, Antananarivo 101 , Madagascar.
T Daniel CrawfordDepartment of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.ORCID 0000-0002-7961-7016
David G I KingstonDepartment of Chemistry and the Virginia Tech Center for Drug Discovery , Virginia Tech , Blacksburg , Virginia 24061 , United States.ORCID 0000-0001-8944-246X

Funding

BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAMEU01TW000313 · FIC · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KINGSTON, DAVID GEORGE IAN · 1993 to 2013
$9.5M
Discovery and Mechanism of Antimalarial Natural ProductsR01AT008088 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CASSERA, MARIA BELEN, CLEMENT, JASON ANDERSON · 2014 to 2018
$2.0M
FIC NIH HHS U01 TW000313NCCIH NIH HHS R01 AT008088
6 · The paper itself

Abstract

Garcinia dauphinensis is a previously uninvestigated endemic plant species of Madagascar. The new phloroglucinols dauphinols A-F and 3'-methylhyperjovoinol B (1-7) and six known phloroglucinols (8-13) together with tocotrienol 14 and the three triterpenoids 15-17 were isolated from an ethanolic extract of G. dauphinensis roots using various chromatographic techniques. The structures of the isolated compounds were elucidated by NMR, MS, optical rotation, and ECD data. Theoretical ECD spectra and specific rotations for 2 were calculated and compared to experimental data in order to assign its absolute configuration. Among the compounds tested, 1 showed the most promising growth inhibitory activity against A2870 ovarian cancer cells, with IC

Indexed as

AntimalarialsAntineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationEthanolGarciniaHumansMolecular StructurePhloroglucinolPlant ExtractsPlant RootsPlasmodium falciparumAntimalarialsAntineoplastic Agents, PhytogenicEthanolPhloroglucinolPlant Extracts

Identifiers

PMID30354100
PMCPMC7053582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.