SynthesisJournal of psychiatry & neuroscience : JPN2019
Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis
Synthesis in Journal of psychiatry & neuroscience : JPN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Cerebral Volumetric Correlates of Apathy in Alzheimer's Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort.Journal of Alzheimer's disease : JAD · 2022Pooled it
- Gray Matter Atrophy in the Cortico-Striatal-Thalamic Network and Sensorimotor Network in Relapsing-Remitting and Primary Progressive Multiple Sclerosis.Neuropsychology review · 2021Pooled it
- Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin.Journal of psychiatric research · 2021Trial
- Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal Positron Emission Tomography-Magnetic Resonance Imaging Study.Biological psychiatry · 2026Article
- Superior frontal and hippocampal structures associated with onset versus recurrence of mood disorders in monozygotic twins.Molecular psychiatry · 2026Article
- Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.American journal of epidemiology · 2026Article
- Cortical Thickness in Middle and Older Aged Adults With Bipolar Disorder Across Six International Sites.Bipolar disorders · 2026Article
- Linking speech patterns to brain structure in affective and psychotic disorders: an integrative natural language processing approach.Molecular psychiatry · 2026Article
- Trace Amine-associated Receptors (TAARs): Candidate Targets in the Treatment of Bipolar Disorders.Actas espanolas de psiquiatria · 2025Review
- Neurostructural Differences Associated With Prodromal Mania Symptoms in Children.Brain and behavior · 2025Review
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- The causal effect of smoking on psychiatric disorders: an examination of brain volume as a potential pathway.Psychological medicine · 2025Article
- Neuroplasticity in chronic pain: insights into diagnosis and treatment.The Korean journal of pain · 2025Article
- Neurocognitive function across different phases of bipolar disorder: an evaluation using the B-CATS.Frontiers in psychiatry · 2025Article
- Machine learning with multiple modalities of brain magnetic resonance imaging data to identify the presence of bipolar disorder.Journal of affective disorders · 2025Article
- Investigating sex-related differences in brain structure and function in bipolar I disorder using multimodal MRI.BMC psychiatry · 2024Article
- A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.American journal of human genetics · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Association of hospitalization with structural brain alterations in patients with affective disorders over nine years.Translational psychiatry · 2023Article
- Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The literature on grey-matter volume alterations in bipolar disorder is heterogeneous in its findings. Methods: Using effect-size differential mapping, we conducted a meta-analysis of grey-matter volume alterations in patients with bipolar disorder compared with healthy controls. Results: We analyzed data from 50 studies that included 1843 patients with bipolar disorder and 2289 controls. Findings revealed lower grey-matter volumes in the bilateral superior frontal gyri, left anterior cingulate cortex and right insula in patients with bipolar disorder and in patients with bipolar disorder type I. Patients with bipolar disorder in the euthymic and depressive phases had spatially distinct regions of altered grey-matter volume. Meta-regression revealed that the proportion of female patients with bipolar disorder or bipolar disorder type I was negatively correlated with regional grey-matter alteration in the right insula; the proportion of patients with bipolar disorder or bipolar disorder type I taking lithium was positively correlated with regional grey-matter alterations in the left anterior cingulate/paracingulate gyri; and the proportion of patients taking antipsychotic medications was negatively correlated with alterations in the anterior cingulate/paracingulate gyri. Limitations: This study was cross-sectional; analysis techniques, patient characteristics and clinical variables in the included studies were heterogeneous. Conclusion: Structural grey-matter abnormalities in patients with bipolar disorder and bipolar disorder type I were mainly in the prefrontal cortex and insula. Patients' mood state might affect grey-matter alterations. Abnormalities in regional grey-matter volume could be correlated with patients' specific demographic and clinical features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.