Evidence map›Paper›PMID 30353771›Full record

SynthesisRenal failure2018

The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis.

I Stefanidis, M Tziastoudi, E E Tsironi, E Dardiotis, S V Tachmitzi, A Fotiadou, G Pissas, K Kytoudis, M Sounidaki, G Ampatzis and 6 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Renal failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. The Role ofGenes · 2026
    Pooled it
  2. The Role ofGenes · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. The Variant T Allele ofBiomolecules · 2026
    Article
  8. Genetic polymorphisms inFrontiers in pharmacology · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

I Stefanidisa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
M Tziastoudib Department of Biomathematics , University of Thessaly School of Medicine , Larissa , Greece.ORCID http://orcid.org/0000-0002-7206-2716
E E Tsironic Department of Ophthalmology , University of Thessaly School of Medicine , Larissa , Greece.
E Dardiotisd Department of Neurology , University of Thessaly School of Medicine , Larissa , Greece.
S V Tachmitzic Department of Ophthalmology , University of Thessaly School of Medicine , Larissa , Greece.
A Fotiadouc Department of Ophthalmology , University of Thessaly School of Medicine , Larissa , Greece.
G Pissasa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
K Kytoudisa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
M Sounidakia Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
G Ampatzisa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
P R Mertense Department of Nephrology , Hypertension, Diabetes and Endocrinology, School of Medicine, University of Magdeburg, Magdeburg , Germany.
V Liakopoulosa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
T Eleftheriadisa Department of Nephrology , University of Thessaly School of Medicine , Larissa , Greece.
G M Hadjigeorgioud Department of Neurology , University of Thessaly School of Medicine , Larissa , Greece.
M Santosf Departament de Genètica i de Microbiologia , Universitat Autònoma de Barcelona , Bellaterra, Spain.
E Zintzarasb Department of Biomathematics , University of Thessaly School of Medicine , Larissa , Greece.
University of Thessaly · GRTufts University · USUniversitat Autònoma de Barcelona · ESUniversity Hospital Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An association study was conducted to investigate the relation between 14 variants of glucose transporter 1 gene (SLC2A1) and the risk of type 2 diabetes (T2DM) leading to nephropathy. We also performed a meta-analysis of 11 studies investigating association between diabetic nephropathy (DN) and SLC2A1 variants. The cohort included 197 cases (T2DM with nephropathy), 155 diseased controls (T2DM without nephropathy) and 246 healthy controls. The association of variants with disease progression was tested using generalized odds ratio (OR

Indexed as

Genetic VariationAgedAged, 80 and overAllelesCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleGene FrequencyGenetic Predisposition to DiseaseGlucose Transporter Type 1HumansLogistic ModelsMaleMiddle AgedRisk FactorsGlucose Transporter Type 1SLC2A1 protein, humanDiabetes mellitusdiabetic nephropathygenetic variants of SLC2A1glucose transporter 1 (GLUT1)

Identifiers

PMID30353771
PMCPMC6201811
OpenAlexW2898279930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.