Evidence map›Paper›PMID 30353641›Full record

ArticleJournal of cellular and molecular medicine2019

Intranasal immunization with Mycobacterium tuberculosis Rv3615c induces sustained adaptive CD4

Jiangping Li, Jun Zhao, Juan Shen, Changyou Wu, Jie Liu

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Interleukin-1 signaling and CD4Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiangping LiInstitute of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.ORCID 0000-0002-6203-1553
Jun ZhaoInstitute of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Juan ShenInstitute of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Changyou WuInstitute of Immunology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Jie LiuLaboratory of Infectious Diseases and Vaccine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-9758-9306
Sun Yat-sen University · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sustained adaptive immunity to pathogens provides effective protection against infections, and effector cells located at the site of infection ensure rapid response to the challenge. Both are essential for the success of vaccine development. To explore new vaccination approach against Mycobacterium tuberculosis (M.tb) infection, we have shown that Rv3615c, identified as ESX-1 substrate protein C of M.tb but not expressed in BCG, induced a dominant Th1-type response of CD4

Indexed as

Adaptive ImmunityAdministration, IntranasalAnimalsAntibody FormationAntigens, BacterialBacterial ProteinsCD4-Positive T-LymphocytesCytokinesFemaleImmunizationImmunologic MemoryLungMiceMice, Inbred C57BLMycobacterium tuberculosisTuberculosis, PulmonaryAntigens, BacterialBacterial ProteinsCytokinesadaptive immunityCD4intranasalmucosalMycobacterium tuberculosisRv3615cTh1

Identifiers

PMID30353641
PMCPMC6307849
OpenAlexW2898545756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.