Evidence map›Paper›PMID 30353632›Full record

ArticleStem cells (Dayton, Ohio)2019

BIN1 Induces the Formation of T-Tubules and Adult-Like Ca

Ana De La Mata, Sendoa Tajada, Samantha O'Dwyer, Collin Matsumoto, Rose E Dixon, Nirmala Hariharan, Claudia M Moreno, Luis Fernando Santana

Open access · bronzeAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

  1. DENND3-p.R534S disrupts dyadic microdomain architecture to drive potentially pro-arrhythmic calcium and electrophysiologic instability.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Article
  3. Article
  4. Nanoscale architecture and dynamics of CaJournal of molecular and cellular cardiology plus · 2025
    Article
  5. Large-scale synthetic data enable digital twins of human excitable cells.bioRxiv : the preprint server for biology · 2025
    Article
  6. Bend it like BIN1: how a membrane-curving adaptor protein shapes cardiac physiology.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. CaCommunications biology · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Evolution of the cardiac dyad.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ana De La MataDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Sendoa TajadaDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Samantha O'DwyerDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Collin MatsumotoDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Rose E DixonDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Nirmala HariharanDepartment of Pharmacology, University of California School of Medicine, Davis, California, USA.ORCID 0000-0001-9314-0253
Claudia M MorenoDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.
Luis Fernando SantanaDepartment of Physiology & Membrane Biology, University of California School of Medicine, Davis, California, USA.ORCID 0000-0002-4297-8029
University of California, Davis · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
NFAT-induced Regional Variations in Kv4 Channel Expression in HeartR01HL085686 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2020
$5.7M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Changes in L-type calcium channels during aging in the heart's pacemakerR00AG056595 · NIA · UNIVERSITY OF WASHINGTON · PI MORENO, CLAUDIA MARCELA · 2019 to 2021
$747k
Changes in L-type calcium channels during aging in the heart's pacemakerK99AG056595 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORENO, CLAUDIA MARCELA · 2017 to 2018
$212k
American Heart Association-American Stroke Association 15SDG25560035NHLBI NIH HHS R01 HL085686NHLBI NIH HHS T32 HL086350NIA NIH HHS K99 AG056595NIA NIH HHS R00 AG056595NIGMS NIH HHS T32 GM099608
6 · The paper itself

Abstract

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are at the center of new cell-based therapies for cardiac disease, but may also serve as a useful in vitro model for cardiac cell development. An intriguing feature of hESC-CMs is that although they express contractile proteins and have sarcomeres, they do not develop transverse-tubules (T-tubules) with adult-like Ca

Indexed as

Adaptor Proteins, Signal TransducingCalciumCalcium SignalingCell DifferentiationHumansMyocytes, CardiacNuclear ProteinsTumor Suppressor ProteinsAdaptor Proteins, Signal TransducingBIN1 protein, humanCalciumNuclear ProteinsTumor Suppressor ProteinsBIN1Calcium release unitsCardiac myocytesCaV1.2hESCT-tubules

Identifiers

PMID30353632
PMCPMC6312737
OpenAlexW2898269107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.