Evidence map›Paper›PMID 30353548›Full record

ArticleBiometrics2019

Informative group testing for multiplex assays.

Christopher R Bilder, Joshua M Tebbs, Christopher S McMahan

Abstract read
In one paragraph

Article in Biometrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Bayesian group testing with dilution effects.Biostatistics (Oxford, England) · 2023
    Article
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  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher R BilderDepartment of Statistics, University of Nebraska-Lincoln, Lincoln, Nebraska 68583.ORCID 0000-0002-2848-8576
Joshua M TebbsDepartment of Statistics, University of South Carolina, Columbia, South Carolina 29208.ORCID 0000-0002-6762-7241
Christopher S McMahanSchool of Mathematical and Statistical Sciences, Clemson University, Clemson, South Carolina 29634.ORCID 0000-0001-5056-9615

Funding

Group testing for infectious disease detection: multiplex assays and back-end screeningR01AI121351 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI BILDER, CHRISTOPHER R · 2016 to 2025
$3.3M
NIAID NIH HHS R01 AI121351
6 · The paper itself

Abstract

Infectious disease testing frequently takes advantage of two tools-group testing and multiplex assays-to make testing timely and cost effective. Until the work of Tebbs et al. (2013) and Hou et al. (2017), there was no research available to understand how best to apply these tools simultaneously. This recent work focused on applications where each individual is considered to be identical in terms of the probability of disease. However, risk-factor information, such as past behavior and presence of symptoms, is very often available on each individual to allow one to estimate individual-specific probabilities. The purpose of our paper is to propose the first group testing algorithms for multiplex assays that take advantage of individual risk-factor information as expressed by these probabilities. We show that our methods significantly reduce the number of tests required while preserving accuracy. Throughout this paper, we focus on applying our methods with the Aptima Combo 2 Assay that is used worldwide for chlamydia and gonorrhea screening.

Indexed as

AlgorithmsChlamydia InfectionsCommunicable DiseasesFemaleGonorrheaHumansMaleMass ScreeningProbabilityRisk Factorscase identificationcorrelated binary datalatent responsepooled testingsensitivityspecificity

Identifiers

PMID30353548
PMCPMC7959482

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.