ArticleHealth services research2018
Antihypertensive Drug Deintensification and Recurrent Falls in Long-Term Care.
Article in Health services research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Deprescribing antihypertensive medications in older people: a systematic review and a meta-analysis.BMC geriatrics · 2026Pooled it
- Effect of pharmacist interventions in chronic kidney disease: a meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Pooled it
- Deprescribing in cardiometabolic conditions in older patients: a systematic review.GeroScience · 2023Pooled it
- Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial.Journal of the American Geriatrics Society · 2020Trial
- Antihypertensive Deprescribing and Functional Status in VA Long-Term Care Residents With and Without Dementia.Journal of the American Geriatrics Society · 2025Article
- Complex Patterns of Antihypertensive Treatment Changes in Long-Term Care Residents.Journal of the American Medical Directors Association · 2024Article
- Deprescribing antihypertensive drugs in frail older adults.Australian prescriber · 2024Review
- Clinician and Family Caregiver Perspectives on Deprescribing Chronic Disease Medications in Older Nursing Home Residents Near the End of Life.Drugs & aging · 2024Article
- Deprescribing research in nursing home residents using routinely collected healthcare data: a conceptual framework.BMC geriatrics · 2023Review
- Preferences for deprescribing antihypertensive medications amongst clinicians, carers and people living with dementia: a discrete choice experiment.Age and ageing · 2023Article
- Trauma-related falls in an urban geriatric population: predictive risk factors for poorer clinical outcomes.Injury epidemiology · 2023Article
- Evaluating alternative methods of comparing antihypertensive treatment intensity.The American journal of managed care · 2022Article
- Deprescribing Blood Pressure Treatment in Long-Term Care Residents.Journal of the American Medical Directors Association · 2021Article
- Clinical outcomes of modifying hypertension treatment intensity in older adults treated to low blood pressure.Journal of the American Geriatrics Society · 2021Article
- Antihypertensive Deprescribing in Older Adult Veterans at End of Life Admitted to Veteran Affairs Nursing Homes.Journal of the American Medical Directors Association · 2021Article
- Root cause analysis of fall-related hospitalisations among residents of aged care services.Aging clinical and experimental research · 2020Article
- Validation of a Health System Measure to Capture Intensive Medication Treatment of Hypertension in the Veterans Health Administration.JAMA network open · 2020Article
- Comparing Outcomes Between Thiazide Diuretics and Other First-line Antihypertensive Drugs in Long-term Nursing Home Residents.Clinical therapeutics · 2020Article
- Hypertension Management in Nursing Homes: Review of Evidence and Considerations for Care.Current hypertension reports · 2020Review
- Hypertension Treatment in US Long-Term Nursing Home Residents With and Without Dementia.Journal of the American Geriatrics Society · 2019Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo examine the relationship between antihypertensive drug deintensification and recurrent falls in long-term care. DATA SOURCES/SETTINGS: Department of Veterans Affairs (VA) inpatient, outpatient, and purchased care data, Minimum Data Set assessments from VA nursing homes (NHs), and Medicare claims from fiscal years 2010 - 2015. STUDY
designWe identified NH residents with evidence of overaggressive antihypertensive treatment, defined as systolic blood pressure (SBP) 80-120 and an index fall. Recurrent fall, hospitalization, and mortality within 30 days were compared between veterans whose antihypertensive medications were deintensified versus those whose antihypertensive medications were not using propensity score methods (PSM). PRINCIPAL
findingsAmong 2,212 NH residents with possibly overaggressive antihypertensive treatment, 11 percent experienced antihypertensive drug deintensification. Lower blood pressure, >1 antihypertensive drug, no congestive heart failure, fracture from index fall, and older age were associated with higher likelihood of deintensification. Antihypertensive deintensification was associated with statistically significant (p-value < .01) lower risk of recurrent fall among residents with SBP 80-100 (marginal effect = -11.4 percent; PSM = -13.6 percent) and higher risk of death among residents with SBP 101-120 (marginal effect = 2.1 percent, p-value = .07; with PSM = 4.3 percent, p-value = .04).
conclusionsResults provide some needed evidence and guidelines for deintensifying antihypertensive medication among frail older residents; since hypertension is prevalent among 54 percent of NH residents, the potential impact of new evidence is great.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.