Evidence map›Paper›PMID 30353471›Full record

ArticleJournal of microbiology (Seoul, Korea)2018

Diagnosis and molecular characteristics of human infections caused by Anaplasma phagocytophilum in South Korea.

Seung Hun Lee, Sungdo Park, Yeong Seon Lee, Hae Kyung Lee, Seon Do Hwang

Abstract read
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In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. The Novel Zoonotic Pathogen,Pathogens (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Seung Hun LeeDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju, 28159, Republic of Korea.
Sungdo ParkDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju, 28159, Republic of Korea.
Yeong Seon LeeDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju, 28159, Republic of Korea.
Hae Kyung LeeDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of Health, Cheongju, 28159, Republic of Korea. hkglee@korea.kr.
Seon Do HwangDivision of Bacterial Diseases, Center for Laboratory control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, 28159, Republic of Korea. hwangsd@korea.kr.
Korea National Institute of Health · KRKorea Disease Control and Prevention Agency · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human granulocytic anaplasmosis (HGA) is a tick borne infection caused by Anaplasma phagocytophilum. HGA cases in South Korea have been identified since the first report in 2014. In this study, we investigated the serological response in 594 clinical samples of patients with acute febrile illness and molecular characteristics of A. phagocytophilum clinical isolates obtained from HGA patients. In serological test for A. phagocytophilum, 7.91% (47/594 cases) were positive for IgG and Ig M and 13 of 47 cases showed seroconversion. In the detection rate of the 16S rRNA, msp2(p44), and ankA, genes were showed 3.68% (14/380 cases) for A. phagocytophilum-specific 16S rRNA gene. Phylogenetic analysis of three clinical isolates demonstrated high sequence similarity (98.58-100%) with A. phagocytophilum 16S rRNA sequences identified from public databases. Analysis of the msp2(p44) gene showed highly variable similarity rates (7.24-98.85%) even within isolated countries and host ranges. These results provide clues into the bacterial characterization of A. phagocytophilum originating from Korean patients, providing useful guidance for treatment and improving clinical outcomes.

Indexed as

Anaplasma phagocytophilumAnaplasmosisBacterial Outer Membrane ProteinsCloning, MolecularDNA, BacterialGenes, BacterialGenetic VariationGenotypeHumansImmunoglobulin GImmunoglobulin MMolecular StructurePhylogenyPolymerase Chain ReactionRepublic of KoreaRNA, Ribosomal, 16SBacterial Outer Membrane ProteinsDNA, BacterialImmunoglobulin GImmunoglobulin Mmsp2 protein, Anaplasma phagocytophilumRNA, Ribosomal, 16SAnaplasma phagocytophilumdiagnosisPCRphylogeny

Identifiers

PMID30353471
OpenAlexW2898245022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.