Evidence map›Paper›PMID 30353366›Full record

ArticleJournal of gastrointestinal cancer2019

Platelet and Neutrophil Counts as Predictive Markers of Neoadjuvant Therapy Efficacy in Rectal Cancer.

AnnaLee Policicchio, Joey Mercier, Antonia Digklia, Ioannis A Voutsadakis

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The Crying Need for a Better Response Assessment in Rectal Cancer.Current treatment options in oncology · 2023
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

AnnaLee PolicicchioDivision of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Joey MercierDivision of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada.
Antonia DigkliaUniversity Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Ioannis A VoutsadakisDivision of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada. ivoutsadakis@yahoo.com.ORCID http://orcid.org/0000-0002-9301-5951

Funding

NOSM NA
6 · The paper itself

Abstract

aimsTo investigate pretreatment platelet and neutrophil counts as well as a combined platelet-neutrophil (PN) index for prognostic information in patients with rectal adenocarcinoma that received neoadjuvant treatment. PATIENTS AND

methodsCharts from 164 patients with localized rectal adenocarcinoma were retrospectively reviewed, and 112 patients with complete data were included in the study. Patients were stratified in groups according to their neutrophil counts, platelet counts, and a combined platelet/neutrophil (PN) index. Baseline parameters of the groups were compared using the x

resultsA total of 33 (29.5%) patients belonged to the high-PN index group, and 79 (70.9%) patients belonged to the low-PN index group. A significant difference was present between the two groups with regard to pathologic response. Patients with both high platelet and high neutrophil counts were less likely to have a complete pathologic response than those in the low-PN index group (P = 0.039). Additionally, tumor location and tumor stage were significantly associated with complete pathologic response to neoadjuvant treatment. Patients with a complete response were more likely to present with a low tumor (≤ 5 cm from the anal verge). Likewise, patients diagnosed with stage II disease were more likely to experience complete response than those diagnosed with stage III (x

conclusionIn this retrospective analysis, the combination of higher platelet and neutrophil counts at the time of diagnosis had predictive value with respect to complete pathologic response to neoadjuvant treatment in locally advanced rectal cancer.

Indexed as

Blood PlateletsNeutrophilsAdenocarcinomaAgedDisease ProgressionFemaleFollow-Up StudiesHumansLeukocyte CountMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPlatelet CountPredictive Value of TestsPreoperative PeriodNeoadjuvant chemoradiationNeutrophilsPlateletsRectal cancerResponse prediction

Identifiers

PMID30353366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.