Evidence map›Paper›PMID 30353350›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2019

Repeated SBRT for in- and out-of-field recurrences in the liver.

Eleni Gkika, Iosif Strouthos, Simon Kirste, Sonja Adebahr, Michael Schultheiss, Dominik Bettinger, Ralph Fritsch, Volker Brass, Lars Maruschke, Hannes Philipp Neeff and 4 more

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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Managing hepatocellular carcinoma across the stages: efficacy and outcomes of stereotactic body radiotherapy : A retrospective study.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eleni GkikaDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany. eleni.gkika@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0001-5455-252X
Iosif StrouthosDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
Simon KirsteDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
Sonja AdebahrDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
Michael SchultheissDepartment of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Medical Center Freiburg, Freiburg, Germany.
Dominik BettingerDepartment of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Medical Center Freiburg, Freiburg, Germany.
Ralph FritschDepartment of Internal Medicine, Hematology, Oncology and Stem-Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany.
Volker BrassDepartment of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Medical Center Freiburg, Freiburg, Germany.
Lars MaruschkeDepartment of Radiology, University Medical Center Freiburg, Freiburg, Germany.
Hannes Philipp NeeffDepartment of General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany.
Sven Arke LangDepartment of General and Visceral Surgery, University Medical Center Freiburg, Freiburg, Germany.
Ursula NestleDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
Anca-Ligia GrosuDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.
Thomas Baptist BrunnerDepartmentof Radiation Oncology, University Medical Center Freiburg, Robert-Koch-Str. 3, 79106, Freiburg im Breisgau, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the feasibility and toxicity profile of repeated stereotactic body radiotherapy (SBRT) for recurrent primary or secondary liver tumors.

methodsConsecutive patients with primary (hepatocellular carcinoma [HCC] or cholangiocarcinoma [CCC]) or secondary liver cancer (LM), with intrahepatic recurrence or progression after SBRT, underwent re-SBRT in 3 to 12 fractions with a median time of 15 (range 2-66) months between treatments.

resultsIn all, 24 patients which were previously treated with SBRT (30 lesions) were retreated with SBRT for "in- and out-of-field" recurrences (2nd SBRT: n = 28, 3rd SBRT: n = 2). The median follow-up after re-irradiation was 14 months. The median prescribed dose for the first SBRT was 46.5 (range 33-66 Gy, EQD2

conclusionsRepeated liver SBRT is feasible, without excessive liver toxicity, when there is no considerable overlapping with pre-irradiated portions of the stomach or bowel and enough time for the liver to regenerate.

Indexed as

AdultAgedAged, 80 and overBile Duct NeoplasmsCarcinoma, HepatocellularCholangiocarcinomaDose Fractionation, RadiationFemaleFollow-Up StudiesGermanyHumansLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalRadiosurgeryCholangiocarcinomaHepatocellular carcinomaLiver metastasesRe-SBRTStereotactic body radiotherapy

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.