Evidence map›Paper›PMID 30353248›Full record

ArticleObesity surgery2019

Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition.

Lee D Ying, Gregory A Breuer, Matthew O Hubbard, Geoffrey S Nadzam, John Hwa, Kathleen A Martin

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lee D YingYale University School of Medicine, New Haven, CT, 06511, USA.
Gregory A BreuerYale University School of Medicine, New Haven, CT, 06511, USA.
Matthew O HubbardYale University School of Medicine, New Haven, CT, 06511, USA.
Geoffrey S NadzamYale University School of Medicine, New Haven, CT, 06511, USA.
John HwaYale University School of Medicine, New Haven, CT, 06511, USA.
Kathleen A MartinYale University School of Medicine, New Haven, CT, 06511, USA. Kathleen.martin@yale.edu.
Yale University · USYale New Haven Health System · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Novel targets of rapamycin and Akt in vascular smooth muscle cell differentiationR01HL091013 · NHLBI · YALE UNIVERSITY · PI MARTIN, KATHLEEN ANN · 2008 to 2017
$4.1M
Hyperglycemia, thromboxane and platelet activity in diabetes mellitusR01HL115247 · NHLBI · YALE UNIVERSITY · PI HWA, JOHN · 2012 to 2019
$3.8M
Platelet Mitochondrial Function in Health and DiseaseR01HL122815 · NHLBI · YALE UNIVERSITY · PI HWA, JOHN · 2015 to 2023
$3.7M
Novel insights into intimal hyperplasia in cardiac allograft vasculopathyR01HL142090 · NHLBI · YALE UNIVERSITY · PI MARTIN, KATHLEEN ANN · 2018 to 2021
$2.4M
Epigenetic control of vascular smooth muscle in cardiovascular diseaseR01HL119529 · NHLBI · YALE UNIVERSITY · PI MARTIN, KATHLEEN ANN · 2014 to 2017
$1.7M
Regulation of vascular smooth muscle cell plasticityR01HL118430 · NHLBI · YALE UNIVERSITY · PI MARTIN, KATHLEEN ANN · 2014 to 2017
$1.7M
Regulation of adipogenesis in obesityby hydroxymethylationF30DK112569 · NIDDK · YALE UNIVERSITY · PI YING, LEE · 2016 to 2017
$60k
NHLBI NIH HHS R01 HL091013NHLBI NIH HHS R01 HL115247NHLBI NIH HHS R01 HL118430NHLBI NIH HHS R01 HL119529NHLBI NIH HHS R01 HL122815NHLBI NIH HHS R01 HL142090NIDDK NIH HHS F30 DK112569NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

backgroundSleeve gastrectomy with ileal transposition has been shown to be superior to sleeve gastrectomy alone for promoting weight loss in rat and porcine models. The absence of a mouse model for this procedure has impeded efforts to understand the molecular physiology underlying its efficacy. This study demonstrates the long-term survivability of sleeve gastrectomy with ileal transposition in mice. MATERIALS AND

methodsIn this study of technical feasibility, a sleeve gastrectomy with ileal transposition (SGIT), sleeve gastrectomy (SG), or sham surgery (SH) was performed on 7- to 8-week-old C57Bl/6J mice (n = 8 for each). To evaluate long-term survivability, mice were placed on an obesogenic diet and weighed weekly for 10 weeks. The intestinal identity of the transposed segment was assessed with gene expression analysis of duodenal-, jejunal-, and ileal-specific hormones using quantitative polymerase chain reaction.

resultsOverall, SGIT better prevented weight gain than the SG or sham procedures (10-week post-operative weight: SH 45.3 ± 1.0 g, SG 41.25 ± 1.6 g, SGIT 35.4 ± 0.8 g). Gene expression pattern analysis of three markers of intestinal identity (gastrin, cholecystokinin, and peptide YY) suggests that the ileal identity of the transposed segment is maintained 10 weeks after transposition.

conclusionsWe demonstrate for the first time a reproducible mouse model of sleeve gastrectomy with ileal transposition. Future studies utilizing this model will expand our understanding of the molecular pathways through which the hindgut regulates satiety.

Indexed as

AnimalsBiomarkersBlood GlucoseCholecystokininDisease Models, AnimalFeasibility StudiesGastrectomyGastrinsGene ExpressionIleumMice, Inbred C57BLPeptide YYRandom AllocationRNAWeight LossBiomarkersBlood GlucoseCholecystokininGastrinsPeptide YYRNAMouse metabolic surgerySleeve gastrectomy with ileal transposition

Identifiers

PMID30353248
PMCPMC6365182
OpenAlexW2896621487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.