ArticleBasic research in cardiology2018
Cardiac mesenchymal cells from diabetic mice are ineffective for cell therapy-mediated myocardial repair.
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Article in Basic research in cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Metabolic regulation for the treatment of ischemic heart disease with stem cells and extracellular vesicles.NPJ cardiovascular health · 2025Review
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- PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction.Molecular and cellular biochemistry · 2023Article
- Progressive stages of dysmetabolism are associated with impaired biological features of human cardiac stromal cells mediated by the oxidative state and autophagy.The Journal of pathology · 2022Article
- Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure.Circulation · 2022Article
- Single dose of synthetic microRNA-199a or microRNA-149 mimic does not improve cardiac function in a murine model of myocardial infarction.Molecular and cellular biochemistry · 2021Article
- Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells.Diabetologia · 2021Article
- Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice.Molecular and cellular biochemistry · 2021Article
- Comparison of One and Three Intraventricular Injections of Cardiac Progenitor Cells in a Murine Model of Chronic Ischemic Cardiomyopathy.Stem cell reviews and reports · 2021Article
- Cardiac Mesenchymal Cells Cultured at Physiologic Oxygen Tension Have Superior Therapeutic Efficacy in Heart Failure Caused by Myocardial Infarction.Frontiers in cell and developmental biology · 2021Article
- Mitochondrial quality control mechanisms as molecular targets in cardiac ischemiaActa pharmaceutica Sinica. B · 2020Review
- Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction.American journal of physiology. Heart and circulatory physiology · 2020Article
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- Resveratrol attenuates cerebral ischaemia reperfusion injury via modulating mitochondrial dynamics homeostasis and activating AMPK-Mfn1 pathway.International journal of experimental pathology · 2019Article
- TrxR2 overexpression alleviates inflammation-mediated neuronal deathToxicology research · 2019Article
- Tanshinone IIA attenuates cardiac microvascular ischemia-reperfusion injury via regulating the SIRT1-PGC1α-mitochondrial apoptosis pathway.Cell stress & chaperones · 2019Article
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- Melatonin ameliorates endoplasmic reticulum stress in N2a neuroblastoma cell hypoxia-reoxygenation injury by activating the AMPK-Pak2 pathway.Cell stress & chaperones · 2019Article
- Nurr1 Promotes Lung Cancer Apoptosis Via Enhancing Mitochondrial Stress and p53-Drp1 Pathway.Open life sciences · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Parul MehraDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Yiru GuoDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Yibing NongDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Pawel LorkiewiczDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Marjan NasrDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Qianhong LiDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Senthilkumar MuthusamyDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
James A BradleyDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Aruni BhatnagarDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Marcin WysoczynskiDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Roberto BolliDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA.
Bradford G HillDivision of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Envirome Institute, Diabetes and Obesity Center, University of Louisville School of Medicine, 580 S. Preston St., Rm 321E, Louisville, KY, 40202, USA. bradford.hill@louisville.edu.
University of Louisville · US
Funding
Tumor Necrosis Factor Modulation of CPCsP01HL078825 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2005 to 2021
$37.6MResearch Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2013 to 2017
$20.1MConProject-006U54HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI BHATNAGAR, ARUNI, ROBERTSON, ROSE MARIE · 2018 to 2022
$18.8MProject 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8MTBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2018 to 2022
$6.3MEndothelial Progenitor Cells and Particulate Air PollutionR01ES019217 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI, O'TOOLE, TIMOTHY E · 2011 to 2022
$6.0MTOXICITY OF 4-HYDROXYALKENALS IN HEARTR01HL055477 · NHLBI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BHATNAGAR, ARUNI · 1997 to 2015
$4.4MUniversity of Louisville Regional Clinical Center for the CCTRNUM1HL113530 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2012 to 2018
$2.9MEffects of Air Pollution on Stem Cell HealthR01ES028268 · NIEHS · UNIVERSITY OF LOUISVILLE · PI HABERZETTL, PETRA, HILL, BRADFORD GUY · 2018 to 2022
$2.2MMetabolic optimization of cell therapyR01HL130174 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2016 to 2020
$1.9MMetabolic regulation of cardiac stem cellsR56HL122580 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY · 2015 to 2015
$381kNHLBI NIH HHS P01 HL078825NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL055477NHLBI NIH HHS R01 HL130174NHLBI NIH HHS R56 HL122580NHLBI NIH HHS U54 HL120163NHLBI NIH HHS UM1 HL113530NIEHS NIH HHS R01 ES019217NIEHS NIH HHS R01 ES028268NIGMS NIH HHS P20 GM103492NIGMS NIH HHS P30 GM127607
Abstract
Although cell therapy improves cardiac function after myocardial infarction, highly variable results and limited understanding of the underlying mechanisms preclude its clinical translation. Because many heart failure patients are diabetic, we examined how diabetic conditions affect the characteristics of cardiac mesenchymal cells (CMC) and their ability to promote myocardial repair in mice. To examine how diabetes affects CMC function, we isolated CMCs from non-diabetic C57BL/6J (CMC
Indexed as
Diabetes Mellitus, ExperimentalMyocardial InfarctionMyocardiumAnimalsFemaleMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLCell therapyExtracellular vesicleGlycolysisHeart failureMetabolismMitochondria
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.