ArticleCurrent microbiology2019
Role of SigB and Staphyloxanthin in Radiation Survival of Staphylococcus aureus.
Article in Current microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- ThebioRxiv : the preprint server for biology · 2026Article
- Staphylococcus aureus's golden-yellow pigment staphyloxanthin: production enhancement, analytical characterization, and biological attributes.Microbial cell factories · 2026Review
- ArlR regulates environmental stress tolerance and biofilm formation in foodborneCurrent research in food science · 2026Article
- Article
- Context matters: assessing the impacts of genomic background and ecology on microbial biosynthetic gene cluster evolution.mSystems · 2025Review
- Phenotypic Variation in ClinicalMicroorganisms · 2023Article
- Identification of staphyloxanthin and derivates in yellow-pigmentedFrontiers in microbiology · 2023Article
- Comparative Transcriptomic Analysis ofFoods (Basel, Switzerland) · 2022Article
- Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Antibiotics (Basel, Switzerland) · 2022Review
- Phenotypic and genomic assessment of the potential threat of human spaceflight-relevantFrontiers in microbiology · 2022Article
- Insights Into the Cultivable Bacterial Fraction of Sediments From the Red Sea Mangroves and Physiological, Chemotaxonomic, and Genomic Characterization ofFrontiers in microbiology · 2022Article
- Small-molecule compound SYG-180-2-2 attenuatesFrontiers in cellular and infection microbiology · 2022Article
- The small molecule ZY-214-4 may reduce the virulence of Staphylococcus aureus by inhibiting pigment production.BMC microbiology · 2021Article
- Measurement of Staphylococcus aureus Pigmentation by Methanol Extraction.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Protective Effect of the Golden Staphyloxanthin Biosynthesis Pathway on Staphylococcus aureus under Cold Atmospheric Plasma Treatment.Applied and environmental microbiology · 2020Article
- Antimicrobial and Antivirulence Action ofFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus is a potent human pathogen. The virulence of this bacterium depends on a multitude of factors that it produces. One such virulence factor is the golden pigment, staphyloxanthin, which has been shown to protect the bacterium from oxidative stress. Expression of the staphyloxanthin biosynthetic pathway is dependent on SigB, a global stress response regulator in S. aureus. This study investigated the role of staphyloxanthin and SigB in protection of S. aureus from radiation damage. Using stationary-phase bacterial cells, it was determined that the staphyloxanthin-deficient (crt mutant) strain was significantly sensitive to UV radiation (~ threefold), but not sensitive to X-radiation. However, a SigB-deficient S. aureus that also lacks staphyloxanthin, was significantly sensitive to both UV- and X-radiation. To confirm that protection from X-radiation was due to hydroxyl radicals, effect of 3 M glycerol, a known hydroxyl scavenger, was also investigated. Glycerol increased the survival of the S. aureus sigB mutant to the wild-type level suggesting that the X-radiation sensitivity of these mutants was due to deficiency in scavenging hydroxyl radicals. In summary, SigB is critical for protection of S. aureus cells from radiation damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.