ArticleNature protocols2018
Design of capillary microfluidics for spinning cell-laden microfibers.
Article in Nature protocols, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 209 citations in OpenAlex.
- Bioinspired hierarchical fibre bundles from microfluidics for nerve regeneration.Bioactive materials · 2026Article
- A Microfluidic Digital Shutter of Liquid-Liquid Interface for Fabrication of Multifaceted Hydrogel Microfiber Structure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cell-instructive microfibers enable programmable alignment of bioprinted hMSC.Bioactive materials · 2026Article
- Bioinspired micro-structured fibers for biomedical applications.Bioactive materials · 2025Review
- Non-Invasive Three-Dimensional Cell Manipulation Technology Based on Acoustic Microfluidic Chips.Micromachines · 2025Article
- Microfluidics-Based Microcarriers for Live-Cell Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization.Lab on a chip · 2025Review
- Hierarchical Micro/Nano-Structured Biomaterials for Wound Healing.Research (Washington, D.C.) · 2025Review
- Micro- and nano-fibers for organ-on-a-chip: Construction, applications, and prospects.Materials today. Bio · 2024Review
- Phase Change Materials Meet Microfluidic Encapsulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- A Cell Pre-Wrapping Seeding Technique for Hydrogel-Based Tubular Organ-On-A-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Flexible liquid-diode microtubes from multimodal microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Controlled oxygen delivery to power tissue regeneration.Nature communications · 2024Review
- Evaluation of Alginate Hydrogel Microstrands for Stromal Cell Encapsulation and Maintenance.Bioengineering (Basel, Switzerland) · 2024Article
- An inexpensive "do-it-yourself" device for rapid generation of uniform tumor spheroids.Device · 2024Article
- Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy.Research (Washington, D.C.) · 2024Review
- Core-Shell Microspheres Prepared Using Coaxial Electrostatic Spray for Local Chemotherapy of Solid Tumors.Pharmaceutics · 2023Article
- Hydrogel fibers for wearable sensors and soft actuators.iScience · 2023Review
- Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications.Military Medical Research · 2023Review
- Porous Structural Microfluidic Device for Biomedical Diagnosis: A Review.Micromachines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This protocol describes the design of capillary microfluidics for spinning bioactive (cell-laden) microfibers for three-dimensional (3D) cell culture and tissue-engineering applications. We describe the assembly of three types of microfluidic systems: (i) simple injection capillary microfluidics for the spinning of uniform microfibers; (ii) hierarchical injection capillary microfluidics for the spinning of core-shell or spindle-knot structured microfibers; and (iii) multi-barrel injection capillary microfluidics for the spinning of microfibers with multiple components. The diverse morphologies of these bioactive microfibers can be further assembled into higher-order structures that are similar to the hierarchical structures in tissues. Thus, by using different types of capillary microfluidic devices, diverse styles of microfibers with different bioactive encapsulation can be generated. These bioactive microfibers have potential applications in 3D cell culture, the mimicking of vascular structures, the creation of synthetic tissues, and so on. The whole protocol for device fabrication and microfiber spinning takes ~1 d.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.