SynthesisMolecular psychiatry2019
Epigenetics in eating disorders: a systematic review.
Synthesis in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Epigenetic alterations in patients with anorexia nervosa-a systematic review.Molecular psychiatry · 2024Pooled it
- Pooled it
- Adolescent disordered eating and epigenetic age acceleration.Molecular psychiatry · 2026Article
- Rethinking crossover and recovery in eating disorders through a dynamic and value-sensitive framework.Medicine, health care, and philosophy · 2026Article
- Recovery From Anorexia Nervosa: A Concept Analysis.Journal of advanced nursing · 2026Review
- Aberrant Expression of Human Endogenous Retroviruses andInternational journal of molecular sciences · 2026Article
- Advancing translational research in binge-eating: Integrating insights from clinical practice into animal models.Translational psychiatry · 2026Review
- Psychopathology and Other Mental Health Challenges in Siblings of Patients with Child- or Adolescent-Onset Anorexia Nervosa: A Systematic Review with a Sex/Gender Perspective.Journal of clinical medicine · 2026Review
- No indications of weight gain associated DNA methylation changes in patients with anorexia nervosa.Scientific reports · 2025Article
- MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies.Genome biology · 2025Article
- An (un)answered cry for help: a qualitative study exploring the subjective meaning of eating disorders in the context of transgenerational trauma.Journal of eating disorders · 2025Article
- Adverse childhood experiences and profiles of healthy orthorexia versus orthorexia nervosa: towards an explanatory model of orthorexia as a multidimensional eating style.Eating and weight disorders : EWD · 2024Article
- Two identical twin pairs discordant for longstanding anorexia nervosa and OSFED: lived experience accounts of eating disorder and recovery processes.Journal of eating disorders · 2024Article
- Causal Relationship between Aging and Anorexia Nervosa: A White-Matter-Microstructure-Mediated Mendelian Randomization Analysis.Biomedicines · 2024Article
- Article
- Cytokine and Microbiome Changes in Adolescents with Anorexia Nervosa at Admission, Discharge, and One-Year Follow-Up.Nutrients · 2024Article
- Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review.Journal of eating disorders · 2024Article
- Temperament impact on eating disorder symptoms and habit formation: a novel model to inform treatment.Journal of eating disorders · 2024Review
- Impact of prematurity on LINE-1 promoter methylation.Epigenomics · 2024Article
- Systematic review of prospective studies assessing risk factors to predict anorexia nervosa onset.Journal of eating disorders · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Eating disorders are complex heritable conditions influenced by both genetic and environmental factors. Given the progress of genomic discovery in anorexia nervosa, with the identification of the first genome-wide significant locus, as well as animated discussion of epigenetic mechanisms in linking environmental factors with disease onset, our goal was to conduct a systematic review of the current body of evidence on epigenetic factors in eating disorders to inform future directions in this area. Following PRISMA guidelines, two independent authors conducted a search within PubMed and Web of Science and identified 18 journal articles and conference abstracts addressing anorexia nervosa (n = 13), bulimia nervosa (n = 6), and binge-eating disorder (n = 1), published between January 2003 and October 2017. We reviewed all articles and included a critical discussion of field-specific methodological considerations. The majority of epigenetic analyses of eating disorders investigated methylation at candidate genes (n = 13), focusing on anorexia and bulimia nervosa in very small samples with considerable sample overlap across published studies. Three studies used microarray-based technologies to examine DNA methylation across the genome of anorexia nervosa and binge-eating disorder patients. Overall, results were inconclusive and were primarily exploratory in nature. The field of epigenetics in eating disorders remains in its infancy. We encourage the scientific community to apply methodologically sound approaches using genome-wide designs including epigenome-wide association studies (EWAS), to increase sample sizes, and to broaden the focus to include all eating disorder types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.