Evidence map›Paper›PMID 30353146›Full record

ArticleScientific reports2018

A role for calcium in resistin transcriptional activation in diabetic hearts.

Rajvir Singh, Pedro Moreno, Roger J Hajjar, Djamel Lebeche

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Restoration of Sarcoplasmic Reticulum CaInternational journal of molecular sciences · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rajvir SinghCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Pedro MorenoCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Roger J HajjarCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Djamel LebecheCardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA. djamel.lebeche@mssm.edu.ORCID http://orcid.org/0000-0002-7911-2923
Icahn School of Medicine at Mount Sinai · US

Funding

TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6M
Targeting Diabetes With Novel SERCA Allosteric ActivatorsR01DK111417 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LEBECHE, DJAMEL · 2018 to 2022
$2.3M
Genetic Analysis of microRNAs Function in Diabetic CardiomyopathyR01HL097357 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL · 2010 to 2014
$2.1M
Molecular and Metabolic phenotype of Impaired AdipoR1 in the HeartR01HL137220 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL097357NHLBI NIH HHS R01 HL137220NHLBI NIH HHS T32 HL007824NIDDK NIH HHS R01 DK111417
6 · The paper itself

Abstract

The adipokine resistin has been proposed to link obesity, insulin resistance and diabetes. We have previously reported that diabetic hearts express high levels of resistin while overexpression of resistin in adult rat hearts gives rise to a phenotype resembling diabetic cardiomyopathy. The transcriptional regulation of resistin in diabetic cardiac tissue is currently unknown. This study investigated the mechanism of resistin upregulation and the role of Serca2a in its transcriptional suppression. We demonstrate that restoration of Ca

Indexed as

Adenylate KinaseAllosteric RegulationAnimalsCalciumDiabetes Mellitus, ExperimentalDiabetic CardiomyopathiesDown-RegulationEnzyme ActivationGlucoseMaleMice, Inbred C57BLMyocardiumNFATC Transcription FactorsOrgan SpecificityPromoter Regions, GeneticRatsAdenylate KinaseCalciumGlucoseNFATC Transcription FactorsResistinSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule Libraries

Identifiers

PMID30353146
PMCPMC6199245
OpenAlexW2896297941

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.