ArticleScientific reports2018
Sensory attenuation in Parkinson's disease is related to disease severity and dopamine dose.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders.Psychiatry and clinical neurosciences · 2024Pooled it
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- Brain Dynamics Underlying Reaching Movements Under Uncertainty.Human brain mapping · 2026Article
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2026Article
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Modest improvement of metabolic and behavioral deficits with long-term ambroxol treatment in a Pink1Acta pharmacologica Sinica · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Vision Fine-Tunes Predictions of Bimanual Self-Touch.The European journal of neuroscience · 2026Article
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Predictive processes linking sense of agency and fatigue: a novel allostatic framework.Frontiers in psychology · 2026Article
- Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson's disease.Scientific reports · 2025Article
- Predictions of bimanual self-touch determine the temporal tuning of somatosensory perception.iScience · 2025Article
- Identification of anatomical locations: its relevance for vibrotactile perception of individuals with Parkinson's disease.Biomedical engineering online · 2025Article
- The role of sensory attenuation in symptomatic and healthy individuals: a scoping review.Frontiers in neuroscience · 2025Review
- Somatosensory processing in long COVID fatigue and its relations with physiological and psychological factors.Experimental physiology · 2024Article
- Hypo-connectivity of the primary somatosensory cortex in Parkinson's disease: a resting-state functional MRI study.Frontiers in neurology · 2024Article
- Aging exerts a limited influence on the perception of self-generated and externally generated touch.Journal of neurophysiology · 2023Article
- Friction and neuroimaging of active and passive tactile touch.Scientific reports · 2023Article
- Voluntary self-initiation of the stimuli onset improves working memory and accelerates visual and attentional processing.Heliyon · 2022Article
- Predictive attenuation of touch and tactile gating are distinct perceptual phenomena.iScience · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Abnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson's disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a 'sensory attenuation'. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger ('Direct' condition) or moved a knob that controlled a motor through a linear potentiometer ('Slider' condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.