Evidence map›Paper›PMID 30353082›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Factors influencing decision making in neonatology: inhaled nitric oxide in preterm infants.

Veena Manja, Gordon Guyatt, Satyan Lakshminrusimha, Susan Jack, Haresh Kirpalani, John A F Zupancic, Dmitry Dukhovny, John J You, Sandra Monteiro

Open access · bronzeAbstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Role of ROS, soluble guanylate cyclase and cGMP in mouse lung development during hyperoxia.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Fundamentals of designing high-quality surveys: revisiting neonatal perinatal medicine survey applications.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. When to say no to inhaled nitric oxide in neonates?Seminars in fetal & neonatal medicine · 2021
    Review
  12. A quality improvement project improving the value of iNO utilization in preterm and term infants.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  13. Review
  14. Article
  15. Prevalence and predictors of donor milk programs among U.S. advanced neonatal care facilities.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Article
  16. Just Say No to iNO in Preterms-Really?The Journal of pediatrics · 2020
    Article
  17. Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  18. Vulnerability of the developing airway.Respiratory physiology & neurobiology · 2019
    Review
  19. [Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Veena ManjaDepartments of Surgery and Pediatrics, University of California at Davis, Sacramento, CA, USA.
Gordon GuyattDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Satyan LakshminrusimhaDepartments of Surgery and Pediatrics, University of California at Davis, Sacramento, CA, USA. slakshmi@ucdavis.edu.
Susan JackDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Haresh KirpalaniDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
John A F ZupancicDepartment of Neonatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Dmitry DukhovnyDepartment of Pediatrics, Oregon Health and Science University, Portland, OR, USA.
John J YouDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Sandra MonteiroDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
McMaster University · CAHarvard University · USImpact · CAOregon Health & Science University · USUniversity of California, Davis · US

Funding

Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
NICHD NIH HHS R01 HD072929
6 · The paper itself

Abstract

objectiveWe studied decision making regarding inhaled nitric oxide (iNO) in preterm infants with Pulmonary Hypertension (PH). STUDY

designWe asked members of the AAP-Society of Neonatal-Perinatal Medicine and Division-Chiefs to select from three management options- initiate iNO, engage parents in shared decision making or not consider iNO in an extremely preterm with PH followed by rating of factors influencing their decision.

resultsThree hundred and four respondents (9%) completed the survey; 36.5% chose to initiate iNO, 42% to engage parents, and 21.5% did not consider iNO. Provider's prior experience, safety, and patient-centered care were rated higher by those who initiated or offered iNO; lack of effectiveness and cost considerations by participants who did not chose iNO.

conclusionsMost neonatologists offer or initiate iNO therapy based on their individual experience. The minority who chose not to consider iNO placed higher value on lack of effectiveness and cost. These results demonstrate a tension between evidence and pathophysiology-based-therapy/personal experience.

Indexed as

Hypertension, PulmonaryIntensive Care, NeonatalRespiratory InsufficiencyAdministration, InhalationAttitude of Health PersonnelClinical Decision-MakingCost-Benefit AnalysisEvidence-Based MedicineFemaleHumansInfant, Extremely PrematureInfant, NewbornInfant, Premature, DiseasesMaleNeonatologyNitric OxideNitric Oxide

Identifiers

PMID30353082
PMCPMC6298829
OpenAlexW2895849566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.