Evidence map›Paper›PMID 30353043›Full record

ArticleBritish journal of cancer2018

Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer.

Gal Shafirstein, David A Bellnier, Emily Oakley, Sasheen Hamilton, Michael Habitzruther, Lawrence Tworek, Alan Hutson, Joseph A Spernyak, Sandra Sexton, Leslie Curtin and 3 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Gal ShafirsteinPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA. Gal.Shafirstein@RoswellPark.org.
David A BellnierPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Emily OakleyPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Sasheen HamiltonPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Michael HabitzrutherPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Lawrence TworekPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Alan HutsonDepartment of Biostatistics and Bioinformatics, Roswell Park, Buffalo, NY, USA.
Joseph A SpernyakDepartment of Cell Stress Biology, Roswell Park, Buffalo, NY, USA.
Sandra SextonLaboratory Animals Shared Resources, Roswell Park, Buffalo, NY, USA.
Leslie CurtinLaboratory Animals Shared Resources, Roswell Park, Buffalo, NY, USA.
Steven G TurowskiTranslational Imaging Shared Resource, Roswell Park, Buffalo, NY, USA.
Hassan ArshadDepartment of Head and Neck Surgery, Roswell Park, Buffalo, NY, USA.
Barbara HendersonPhotodynamic Therapy Center, Roswell Park Comprehensive Cancer Center (Roswell Park), Buffalo, NY, USA.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
StatisticsP01CA055791 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GOLLNICK, SANDRA O. · 1992 to 2019
$36.0M
Integrated Image-guided Dosimetry & Treatment Planning PDTR01CA193610 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI SHAFIRSTEIN, GAL · 2016 to 2020
$2.5M
NCI NIH HHS P01 CA055791NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA193610
6 · The paper itself

Abstract

backgroundCurrently delivered light dose (J/cm

methodsFinite-element modeling was used to compute intratumoural irradiance and dose to guide Photofrin

resultsIn the mouse model, cure rates of 70-90% were obtained with I-PDT using 8.4-245 mW/cm

conclusionIn Photofrin

Indexed as

PhotochemotherapyAnimalsCarcinoma, Squamous CellDihematoporphyrin EtherFemaleHot TemperatureMiceMice, Inbred C3HNeoplasms, ExperimentalPhotosensitizing AgentsRabbitsThermometryDihematoporphyrin EtherPhotosensitizing Agents

Identifiers

PMID30353043
PMCPMC6251027
OpenAlexW2897065161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.