ArticleScientific reports2018
Characterization of the miRNA regulators of the human ovulatory cascade.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Studying ovarian aging and its health impacts: modern tools and approaches.Genes & development · 2025Review
- Dynamic microRNA expression profiles in goat ovarian tissues before and after pregnancy.Journal of animal science · 2025Article
- DNA methylation, but not microRNA expression, is affected by in vitro THC exposure in bovine granulosa cells.BMC pharmacology & toxicology · 2024Article
- Identification of Potentially Novel Molecular Targets of Endometrial Cancer Using a Non-Biased Proteomic Approach.Cancers · 2023Article
- The relationship between miR-21, DNA methylation, and bisphenol a in bovine COCs and granulosa cells.Frontiers in cell and developmental biology · 2023Article
- Article
- Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility.Biomedicines · 2022Article
- Multimerin-1 and cancer: a review.Bioscience reports · 2022Review
- Combined Transcriptomic and Metabolomic Analysis of Women with Polycystic Ovary Syndrome.Disease markers · 2022Article
- New biomarkers in peripheral blood of patients with ovarian cancer: high expression levels of miR-16-5p, miR-17-5p, and miR-638.Archives of gynecology and obstetrics · 2022Article
- Multi-Omics Analysis and Machine Learning Prediction Model for Pregnancy Outcomes After Intracytoplasmic Sperm Injection-Frontiers in public health · 2022Article
- Genetic Basis of Follicle Development in Dazu Black Goat by Whole-Transcriptome Sequencing.Animals : an open access journal from MDPI · 2021Article
- Oxidized high-density lipoprotein enhances endocrine disorders and ovarian damage in rats.Journal of cellular and molecular medicine · 2021Article
- Age-related miRNome landscape of cumulus oophorus cells during controlled ovarian stimulation protocols in IVF cycles.Human reproduction (Oxford, England) · 2021Article
- Identification of the Key microRNAs and miRNA-mRNA Interaction Networks during the Ovarian Development of Hens.Animals : an open access journal from MDPI · 2020Article
- Transcriptomics of cumulus cells - a window into oocyte maturation in humans.Journal of ovarian research · 2020Article
- Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells.Scientific reports · 2020Article
- MicroRNAs: potential targets and agents of endocrine disruption in female reproduction.Journal of toxicologic pathology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Ovarian follicular development and ovulation are complex and tightly regulated processes that involve regulation by microRNAs (miRNAs). We previously identified differentially expressed mRNAs between human cumulus granulosa cells (CGCs) from immature early antral follicles (germinal vesicle - GV) and mature preovulatory follicles (metaphase II - M2). In this study, we performed an integrated analysis of the transcriptome and miRNome in CGCs obtained from the GV cumulus-oocyte complex (COC) obtained from IVM and M2 COC obtained from IVF. A total of 43 differentially expressed miRNAs were identified. Using Ingenuity IPA analysis, we identified 7288 potential miRNA-regulated target genes. Two hundred thirty-four of these target genes were also found in our previously generated ovulatory gene library while exhibiting anti-correlated expression to the identified miRNAs. IPA pathway analysis suggested that miR-21 and FOXM1 cooperatively inhibit CDC25A, TOP2A and PRC1. We identified a mechanism for the temporary inhibition of VEGF during ovulation by TGFB1, miR-16-5p and miR-34a-5p. The linkage bioinformatics analysis between the libraries of the coding genes from our preliminary study with the newly generated library of regulatory miRNAs provides us a comprehensive, integrated overview of the miRNA-mRNA co-regulatory networks that may play a key role in controlling post-transcriptomic regulation of the ovulatory process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.